Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3784287..3785104 Replicon chromosome
Accession NZ_CP064832
Organism Morganella morganii subsp. morganii strain 12304

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag IZ182_RS18200 Protein ID WP_015422406.1
Coordinates 3784287..3784793 (-) Length 169 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID J7TDK6
Locus tag IZ182_RS18205 Protein ID WP_004236533.1
Coordinates 3784796..3785104 (-) Length 103 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IZ182_RS18165 (IZ182_18175) 3779651..3780274 - 624 WP_004236525.1 thiol:disulfide interchange protein DsbA -
IZ182_RS18170 (IZ182_18180) 3780293..3781288 - 996 WP_004236526.1 serine/threonine protein kinase -
IZ182_RS18175 (IZ182_18185) 3781288..3781557 - 270 WP_004240741.1 YihD family protein -
IZ182_RS19145 3781778..3782350 + 573 Protein_3541 molybdenum cofactor guanylyltransferase MobA -
IZ182_RS19150 3782357..3782875 + 519 WP_225806429.1 molybdopterin-guanine dinucleotide biosynthesis protein MobB -
IZ182_RS18185 (IZ182_18195) 3783085..3783387 + 303 WP_004236529.1 HdeA/HdeB family chaperone -
IZ182_RS18190 (IZ182_18200) 3783515..3784036 + 522 WP_015422407.1 isopentenyl-diphosphate Delta-isomerase -
IZ182_RS18195 3784033..3784173 + 141 WP_004236531.1 hypothetical protein -
IZ182_RS18200 (IZ182_18210) 3784287..3784793 - 507 WP_015422406.1 GNAT family N-acetyltransferase Toxin
IZ182_RS18205 (IZ182_18215) 3784796..3785104 - 309 WP_004236533.1 DUF1778 domain-containing protein Antitoxin
IZ182_RS18210 (IZ182_18220) 3785236..3786588 - 1353 WP_004236534.1 glutathione-disulfide reductase -
IZ182_RS18215 (IZ182_18225) 3786658..3787500 - 843 WP_004236535.1 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ -
IZ182_RS18220 (IZ182_18230) 3787690..3788079 + 390 WP_004236536.1 DUF1090 domain-containing protein -
IZ182_RS18225 (IZ182_18235) 3788491..3789483 + 993 WP_004236539.1 inner membrane protein YhjD -
IZ182_RS18230 (IZ182_18240) 3789591..3789797 + 207 WP_004236540.1 4-oxalocrotonate tautomerase family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(44-143)

Antitoxin

(21-94)


Sequences


Toxin        


Download         Length: 169 a.a.        Molecular weight: 18565.43 Da        Isoelectric Point: 9.9508

>T181807 WP_015422406.1 NZ_CP064832:c3784793-3784287 [Morganella morganii subsp. morganii]
MNLTAPEPLQQHHDFTVFQSGEESLNHWLKTRALQNQQSGASRTFVVCHHNRIMAYYALSTGVITCSQAAGRFRRNMPPE
IPVILPGRLAVDESVKGRGIGRGLIKDAALRVLQAAGIVGIRGIVVRALSDNARRFYEHTGFMPSPADPMLLMITLRDLQ
LATGIYSE

Download         Length: 507 bp

>T181807 NZ_CP086177:c2966515-2966147 [Streptomyces fungicidicus]
ATGTACTACCTCACCTTGCCCGAGTTGCTGAACCTCGCGAAGCGGCTCGGGGAGGACGTGGTGCGCGACTACGGGCTGCT
CGACTCGGCCTTGGCGCGTCCGCAGTCGAGCGTGTTCGGCCAGGACGCCTACCCGGACGTGTGGCAGAAGGCCGCGGCAC
TGATGGAGTCCCTCGCTCGCAACCATGCCCTCGTCGACGGGAACAAGCGCCTCGCCTGGTACGCGACCTGGGTCTTCCTG
CATATGAACGGGCATCCGCTCGACCCGGACTTCGACGTGGACGAGGCGGAGCAGTTCGTGCTGGACGTCTGCCAGGGCGC
ACTGGACGTCCCCAAGATCGCAGCTCAGTTGCCCCGCTTCGCGCGCTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11499.15 Da        Isoelectric Point: 8.6397

>AT181807 WP_004236533.1 NZ_CP064832:c3785104-3784796 [Morganella morganii subsp. morganii]
MTKHTDEQHPVSGVNITRSTLNLRIKPEDKILIDRAAHAAGKNRTEFVLEAARRAAEETLADLRVIDVSTDVYQQFITRL
DMAPQSGEALKKTMLTKAPWEK

Download         Length: 309 bp

>AT181807 NZ_CP086177:c2966712-2966515 [Streptomyces fungicidicus]
ATGGCTGGACTGAACCTGCGGTTTACTGACGAAGAGCTCGATGCCCTGCGTGAGCGTGCGGCTGCGGAAGGGCGCAGCAT
GCAGACCTTCGCGCACGACGCGGTGATCAAGGCCATAAACGAACACTCGAGGCTGTTCAACGAGGCGGCCGACCACGTGC
TGAGGGCCAGCGAAGAGCTGAACCGGAGGCTCGCCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB J7TDK6

References