Detailed information of TA system TA181806

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 939357..939840
• Replicon: chromosome
• Accession: NZ_CP064832
• Organism: Morganella morganii subsp. morganii strain 12304

Toxin (Protein)

• Gene name: relE
• Uniprot ID: J7TMG3
• Locus tag: IZ182_RS04310
• Protein ID: WP_004237651.1
• Coordinates: 939613..939840 (+)
• Length: 76 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: IZ182_RS04305
• Protein ID: WP_015422945.1
• Coordinates: 939357..939629 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IZ182_RS04300 (IZ182_04300)	934514..939148	+	4635	WP_004237649.1	hemagglutinin repeat-containing protein	-
IZ182_RS04305 (IZ182_04305)	939357..939629	+	273	WP_015422945.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
IZ182_RS04310 (IZ182_04310)	939613..939840	+	228	WP_004237651.1	type II toxin-antitoxin system YafQ family toxin	Toxin
IZ182_RS04315 (IZ182_04315)	940143..941627	+	1485	WP_004237652.1	C69 family dipeptidase	-
IZ182_RS04320 (IZ182_04320)	941693..942145	-	453	WP_004237653.1	NfeD family protein	-
IZ182_RS04325 (IZ182_04325)	942142..943080	-	939	WP_004237654.1	SPFH domain-containing protein	-
IZ182_RS04330 (IZ182_04330)	943136..943993	-	858	WP_015422944.1	co-chaperone YbbN	-
IZ182_RS04335 (IZ182_04335)	944053..944838	-	786	WP_214183551.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-74)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (2-78)

Sequences

Toxin

Protein

• Length: 76 a.a.
• Molecular weight: 9069.63 Da
• Isoelectric Point: 9.9416

>T181806 WP_004237651.1 NZ_CP064832:939613-939840 [Morganella morganii subsp. morganii]
MARTIERSSQFKKDYKREVKGIYRMMLNDSLQNILNILVNDLPIPEKYADHPLKGNWRTFRDCHLYPDLILIYKK

Nucleotide

• Length: 228 bp

>T181806 NZ_CP086176:4034214-4034624 [Streptomyces fungicidicus]
GTGATCTACCTGCTCGACACGTCCGGCCTGGTCCGGCTGCTCCGCGATCCGAAACTGCAATCGGCCTGGTACGACGCGAT
CGATGCCGGGGCCATCGCATCCTGCTACGTGCAACGCGCCGAGTTCCTCCACAGTGCCCGGAACGGGCGCGAGTACGACG
AGATCACGGAAATGTTCACCGACCTCTACCCCGACGTGTCGGTACCGAAGAACGCGGGGCGCTGGATCGGCGCGGTGCAG
CACCGCATGGCTCGGGCAGGGGAGCATCGCAGCGCCTCGGCGGTGGACCTCCTCATCGCCGCCACCGCGGCCCACCATGG
CCTGGCTGTCCTCCACGATGATGCCGACTATCGGGCGATTGCCCGGCACGCATCCGACCTGACCGAGCACAACGTCCACG
ACATCGCTTGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10091.70 Da
• Isoelectric Point: 5.1746

>AT181806 WP_015422945.1 NZ_CP064832:939357-939629 [Morganella morganii subsp. morganii]
VEYVRAKIDPKLKAEAIETLESMGLTVSDAIRMLMIQIVEQKAMPFCVKSTQYRHAARTRAAIEELECGKGKKFDSISDL
MADLQDGKDD

Nucleotide

• Length: 273 bp

>AT181806 NZ_CP086176:4033996-4034217 [Streptomyces fungicidicus]
ATGTCCGTGACTCAGATTGACATCGACGACGACGCCCTGGAGCGAGCCATGGCTCTGGCCCACGTCCGGACCAAGAAGGA
GGCGGTCAACCTCGCTCTGAATTTCTATGCCGAGCAGCAGGAGCGTGCGGCGCGCATCAGCCGTCACTTCGAGCGTGCCC
GTGAGTGGGGTGCCGTTGAGGACGCCGAGCGTCTGCACAGGGCGGAGAAGCGCAACCGGTGA

Structures

Toxin

• AlphaFold DB: J7TMG3