Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 895379..896005 Replicon chromosome
Accession NZ_CP064832
Organism Morganella morganii subsp. morganii strain 12304

Toxin (Protein)


Gene name Hha Uniprot ID A0A0A2RCL2
Locus tag IZ182_RS04160 Protein ID WP_024474604.1
Coordinates 895379..895582 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J7U1S9
Locus tag IZ182_RS04165 Protein ID WP_004236473.1
Coordinates 895646..896005 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IZ182_RS04140 (IZ182_04140) 891935..892273 + 339 WP_004236467.1 P-II family nitrogen regulator -
IZ182_RS04145 (IZ182_04145) 892293..893582 + 1290 WP_015422958.1 ammonium transporter AmtB -
IZ182_RS04150 (IZ182_04150) 893643..894506 - 864 WP_004236469.1 acyl-CoA thioesterase II -
IZ182_RS04160 (IZ182_04160) 895379..895582 - 204 WP_024474604.1 HHA domain-containing protein Toxin
IZ182_RS04165 (IZ182_04165) 895646..896005 - 360 WP_004236473.1 Hha toxicity modulator TomB Antitoxin
IZ182_RS04170 (IZ182_04170) 896568..899744 - 3177 WP_015422956.1 efflux RND transporter permease subunit -
IZ182_RS04175 (IZ182_04175) 899759..900955 - 1197 WP_015422955.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-113)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8073.39 Da        Isoelectric Point: 6.9770

>T181805 WP_024474604.1 NZ_CP064832:c895582-895379 [Morganella morganii subsp. morganii]
MTKLDYLMRLRKCTSIETLERVIEKNKYELTDDELEVFYSAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

>T181805 NZ_CP086176:3242205-3242471 [Streptomyces fungicidicus]
GTGAGTAGCGGCTACCGCACCGTCTTCCGGCCGGAGGCTCAGGCGGAGCTTCGCAAGATTCCCCGGGACATGGCCCTGAG
GATCCTGGTCAAACTGACGGAACTGGAAACGGACCCGCTCGGCTTCCGCACCACGGCGCTCGTCTCCCGGCCCGACCGGC
GCCGGCTCCGTGTCGGCGACTACCGCGTCATCTACACGATCGACAACGGCGAGTTGACGGTCTGGGTCGTTCATGTCGGA
CACCGCTCCACGGTATACGACACCTGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13826.54 Da        Isoelectric Point: 4.2870

>AT181805 WP_004236473.1 NZ_CP064832:c896005-895646 [Morganella morganii subsp. morganii]
MDEYSPRNYDIAVLKYLCDELCREGTQTLIRSNNYWVNDLASDSNLKLNELLGYIADVAWSFKIKHTQNKDLISFVDEYI
DETYALFGQMEVSFNDVEEWKKMASLVSSMLTSEGHLVH

Download         Length: 360 bp

>AT181805 NZ_CP086176:3241946-3242212 [Streptomyces fungicidicus]
ATGACCGAGATGCCCATAGAGTCCATTCGTGACGTGCGCGCCCACCTGGCCGAGGTGGTCGAACGGGCGGACCGGGACGA
CACGCCCACGGTCATCACCCGGCGAGGCAAGCAGGTGGCCGCAGTCGTGTCGATGGAGGTCCTTCGCAAGTACCAGGAAT
GGGAAGAGCGCGAGATCAACCGGATCATCGACGAGCGCATGGCGAACCCGGCAGCCGGTATCCCGATCGAGGACGTCATG
CGGGAGACGCTGGAGCGCGGTGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A2RCL2

Antitoxin

Source ID Structure
AlphaFold DB J7U1S9

References