Detailed information of TA system TA181804

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 3636699..3637351
• Replicon: chromosome
• Accession: NZ_CP064831
• Organism: Morganella morganii subsp. morganii strain ZJG812

Toxin (Protein)

• Gene name: TacT2
• Uniprot ID: -
• Locus tag: IZ184_RS17290
• Protein ID: WP_080939504.1
• Coordinates: 3636699..3637046 (-)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: TacA2
• Uniprot ID: -
• Locus tag: IZ184_RS17295
• Protein ID: WP_163654117.1
• Coordinates: 3637046..3637351 (-)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IZ184_RS17255 (IZ184_17260)	3632064..3632687	-	624	WP_004236525.1	thiol:disulfide interchange protein DsbA	-
IZ184_RS17260 (IZ184_17265)	3632706..3633701	-	996	WP_004236526.1	serine/threonine protein kinase	-
IZ184_RS17265 (IZ184_17270)	3633701..3633970	-	270	WP_004240741.1	YihD family protein	-
IZ184_RS18230	3634191..3634763	+	573	Protein_3346	molybdenum cofactor guanylyltransferase MobA	-
IZ184_RS18235	3634770..3635288	+	519	WP_225806429.1	molybdopterin-guanine dinucleotide biosynthesis protein MobB	-
IZ184_RS17275 (IZ184_17280)	3635498..3635800	+	303	WP_004236529.1	HdeA/HdeB family chaperone	-
IZ184_RS17280 (IZ184_17285)	3635928..3636449	+	522	WP_163654114.1	isopentenyl-diphosphate Delta-isomerase	-
IZ184_RS17285 (IZ184_17290)	3636446..3636691	+	246	WP_163652604.1	hypothetical protein	-
IZ184_RS17290 (IZ184_17295)	3636699..3637046	-	348	WP_080939504.1	GNAT family N-acetyltransferase	Toxin
IZ184_RS17295 (IZ184_17300)	3637046..3637351	-	306	WP_163654117.1	DUF1778 domain-containing protein	Antitoxin
IZ184_RS17300 (IZ184_17305)	3637483..3638835	-	1353	WP_004236534.1	glutathione-disulfide reductase	-
IZ184_RS17305 (IZ184_17310)	3638905..3639747	-	843	WP_036417394.1	23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ	-
IZ184_RS17310 (IZ184_17315)	3639937..3640326	+	390	WP_081119805.1	DUF1090 domain-containing protein	-
IZ184_RS17315 (IZ184_17320)	3640738..3641730	+	993	WP_049242212.1	inner membrane protein YhjD	-
IZ184_RS17320 (IZ184_17325)	3641838..3642044	+	207	WP_004236540.1	4-oxalocrotonate tautomerase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (28-90)

Antitoxin

• Vibrio phage ICP1, Orf50 (21-91)

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 12424.59 Da
• Isoelectric Point: 10.3028

>T181804 WP_080939504.1 NZ_CP064831:c3637046-3636699 [Morganella morganii subsp. morganii]
MAYYALSTGVITCSQAAGRFRRNMPPEIPVILPGRLAVDESVKGRGIGRGLIKDAALRVLQAAGIVGIRGIVVRALSDNA
RRFYEHTGFIPSPADPMLLMITLRDLQLATGIYSE

Nucleotide

• Length: 348 bp

>T181804 NZ_CP086176:c2966508-2966140 [Streptomyces fungicidicus]
ATGTACTACCTCACCTTGCCCGAGTTGCTGAACCTCGCGAAGCGGCTCGGGGAGGACGTGGTGCGCGACTACGGGCTGCT
CGACTCGGCCTTGGCGCGTCCGCAGTCGAGCGTGTTCGGCCAGGACGCCTACCCGGACGTGTGGCAGAAGGCCGCGGCAC
TGATGGAGTCCCTCGCTCGCAACCATGCCCTCGTCGACGGGAACAAGCGCCTCGCCTGGTACGCGACCTGGGTCTTCCTG
CATATGAACGGGCATCCGCTCGACCCGGACTTCGACGTGGACGAGGCGGAGCAGTTCGTGCTGGACGTCTGCCAGGGCGC
ACTGGACGTCCCCAAGATCGCAGCTCAGTTGCCCCGCTTCGCGCGCTGA

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 11146.57 Da
• Isoelectric Point: 6.6439

>AT181804 WP_163654117.1 NZ_CP064831:c3637351-3637046 [Morganella morganii subsp. morganii]
MTKHTDEQHPVSGVNITRSTLNLRIKPEDKILIDRAAHAAGKNRTEFVLEAARRAAEETLADLRVIDVSTDVYQQFITRL
DMAPQSGEALHGHLSSVTITG

Nucleotide

• Length: 306 bp

>AT181804 NZ_CP086176:c2966705-2966508 [Streptomyces fungicidicus]
ATGGCTGGACTGAACCTGCGGTTTACTGACGAAGAGCTCGATGCCCTGCGTGAGCGTGCGGCTGCGGAAGGGCGCAGCAT
GCAGACCTTCGCGCACGACGCGGTGATCAAGGCCATAAACGAACACTCGAGGCTGTTCAACGAGGCGGCCGACCACGTGC
TGAGGGCCAGCGAAGAGCTGAACCGGAGGCTCGCCTGA