Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3778842..3779659 Replicon chromosome
Accession NZ_CP064829
Organism Morganella morganii subsp. morganii strain 621164

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag IZ188_RS17995 Protein ID WP_181407372.1
Coordinates 3778842..3779348 (-) Length 169 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID J7TDK6
Locus tag IZ188_RS18000 Protein ID WP_004236533.1
Coordinates 3779351..3779659 (-) Length 103 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IZ188_RS17960 (IZ188_17955) 3774206..3774829 - 624 WP_004236525.1 thiol:disulfide interchange protein DsbA -
IZ188_RS17965 (IZ188_17960) 3774848..3775843 - 996 WP_112548543.1 serine/threonine protein kinase -
IZ188_RS17970 (IZ188_17965) 3775843..3776112 - 270 WP_004240741.1 YihD family protein -
IZ188_RS19075 3776333..3776905 + 573 Protein_3500 molybdenum cofactor guanylyltransferase MobA -
IZ188_RS19080 3776912..3777430 + 519 WP_225904205.1 molybdopterin-guanine dinucleotide biosynthesis protein MobB -
IZ188_RS17980 (IZ188_17975) 3777640..3777942 + 303 WP_004240743.1 HdeA/HdeB family chaperone -
IZ188_RS17985 (IZ188_17980) 3778070..3778591 + 522 WP_015422407.1 isopentenyl-diphosphate Delta-isomerase -
IZ188_RS17990 3778588..3778728 + 141 WP_004236531.1 hypothetical protein -
IZ188_RS17995 (IZ188_17990) 3778842..3779348 - 507 WP_181407372.1 GNAT family N-acetyltransferase Toxin
IZ188_RS18000 (IZ188_17995) 3779351..3779659 - 309 WP_004236533.1 DUF1778 domain-containing protein Antitoxin
IZ188_RS18005 (IZ188_18000) 3779791..3781143 - 1353 WP_046024838.1 glutathione-disulfide reductase -
IZ188_RS18010 (IZ188_18005) 3781213..3782055 - 843 WP_004236535.1 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ -
IZ188_RS18015 (IZ188_18010) 3782245..3782634 + 390 WP_004236536.1 DUF1090 domain-containing protein -
IZ188_RS18020 (IZ188_18015) 3783046..3784038 + 993 WP_032098000.1 inner membrane protein YhjD -
IZ188_RS18025 (IZ188_18020) 3784146..3784352 + 207 WP_004236540.1 4-oxalocrotonate tautomerase family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(44-143)

Antitoxin

(21-94)


Sequences


Toxin        


Download         Length: 169 a.a.        Molecular weight: 18547.40 Da        Isoelectric Point: 9.9508

>T181801 WP_181407372.1 NZ_CP064829:c3779348-3778842 [Morganella morganii subsp. morganii]
MNLTAPEPLQQHHDFTVFQSGEESLNHWLKTRALQNQQSGASRTFVVCHHNRIMAYYALSTGVITCSQAAGRFRRNMPPE
IPVILPGRLAVDESVKGRGIGRGLIKDAALRVLQAAGIVGIRGIVVRALSDNARRFYEHTGFIPSPADPMLLMITLRDLQ
LATGIYSE

Download         Length: 507 bp

>T181801 NZ_CP086175:c2966082-2965714 [Streptomyces fungicidicus]
ATGTACTACCTCACCTTGCCCGAGTTGCTGAACCTCGCGAAGCGGCTCGGGGAGGACGTGGTGCGCGACTACGGGCTGCT
CGACTCGGCCTTGGCGCGTCCGCAGTCGAGCGTGTTCGGCCAGGACGCCTACCCGGACGTGTGGCAGAAGGCCGCGGCAC
TGATGGAGTCCCTCGCTCGCAACCATGCCCTCGTCGACGGGAACAAGCGCCTCGCCTGGTACGCGACCTGGGTCTTCCTG
CATATGAACGGGCATCCGCTCGACCCGGACTTCGACGTGGACGAGGCGGAGCAGTTCGTGCTGGACGTCTGCCAGGGCGC
ACTGGACGTCCCCAAGATCGCAGCTCAGTTGCCCCGCTTCGCGCGCTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11499.15 Da        Isoelectric Point: 8.6397

>AT181801 WP_004236533.1 NZ_CP064829:c3779659-3779351 [Morganella morganii subsp. morganii]
MTKHTDEQHPVSGVNITRSTLNLRIKPEDKILIDRAAHAAGKNRTEFVLEAARRAAEETLADLRVIDVSTDVYQQFITRL
DMAPQSGEALKKTMLTKAPWEK

Download         Length: 309 bp

>AT181801 NZ_CP086175:c2966279-2966082 [Streptomyces fungicidicus]
ATGGCTGGACTGAACCTGCGGTTTACTGACGAAGAGCTCGATGCCCTGCGTGAGCGTGCGGCTGCGGAAGGGCGCAGCAT
GCAGACCTTCGCGCACGACGCGGTGATCAAGGCCATAAACGAACACTCGAGGCTGTTCAACGAGGCGGCCGACCACGTGC
TGAGGGCCAGCGAAGAGCTGAACCGGAGGCTCGCCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB J7TDK6

References