Detailed information of TA system TA181798

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 3740531..3741183
• Replicon: chromosome
• Accession: NZ_CP064828
• Organism: Morganella morganii subsp. morganii strain ZJC25

Toxin (Protein)

• Gene name: TacT2
• Uniprot ID: -
• Locus tag: IZ183_RS18125
• Protein ID: WP_081113485.1
• Coordinates: 3740531..3740878 (-)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: TacA2
• Uniprot ID: A0A447J977
• Locus tag: IZ183_RS18130
• Protein ID: WP_062773288.1
• Coordinates: 3740878..3741183 (-)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IZ183_RS18095 (IZ183_18085)	3735895..3736518	-	624	WP_004236525.1	thiol:disulfide interchange protein DsbA	-
IZ183_RS18100 (IZ183_18090)	3736537..3737532	-	996	WP_004236526.1	serine/threonine protein kinase	-
IZ183_RS18105 (IZ183_18095)	3737532..3737801	-	270	WP_004240741.1	YihD family protein	-
IZ183_RS19330	3738022..3738594	+	573	Protein_3528	molybdenum cofactor guanylyltransferase MobA	-
IZ183_RS19335	3738601..3739119	+	519	WP_225310111.1	molybdopterin-guanine dinucleotide biosynthesis protein MobB	-
IZ183_RS18115 (IZ183_18105)	3739329..3739631	+	303	WP_004236529.1	HdeA/HdeB family chaperone	-
IZ183_RS18120 (IZ183_18110)	3739759..3740280	+	522	WP_049246570.1	isopentenyl-diphosphate Delta-isomerase	-
IZ183_RS18125 (IZ183_18115)	3740531..3740878	-	348	WP_081113485.1	GNAT family N-acetyltransferase	Toxin
IZ183_RS18130 (IZ183_18120)	3740878..3741183	-	306	WP_062773288.1	DUF1778 domain-containing protein	Antitoxin
IZ183_RS18135 (IZ183_18125)	3741315..3742667	-	1353	WP_004236534.1	glutathione-disulfide reductase	-
IZ183_RS18140 (IZ183_18130)	3742737..3743579	-	843	WP_036417394.1	23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ	-
IZ183_RS18145 (IZ183_18135)	3743769..3744158	+	390	WP_004236536.1	DUF1090 domain-containing protein	-
IZ183_RS18150 (IZ183_18140)	3744570..3745562	+	993	WP_049242212.1	inner membrane protein YhjD	-
IZ183_RS18155 (IZ183_18145)	3745670..3745876	+	207	WP_004236540.1	4-oxalocrotonate tautomerase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (28-90)

Antitoxin

• Vibrio phage ICP1, Orf50 (21-91)

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 12442.62 Da
• Isoelectric Point: 10.3028

>T181798 WP_081113485.1 NZ_CP064828:c3740878-3740531 [Morganella morganii subsp. morganii]
MAYYALSTGVITCSQAAGRFRRNMPPEIPVILPGRLAVDESVKGRGIGRGLIKDAALRVLQAAGIVGIRGIVVRALSDNA
RRFYEHTGFMPSPADPMLLMITLRDLQLATGIYSE

Nucleotide

• Length: 348 bp

>T181798 NZ_CP086174:c2966080-2965712 [Streptomyces fungicidicus]
ATGTACTACCTCACCTTGCCCGAGTTGCTGAACCTCGCGAAGCGGCTCGGGGAGGACGTGGTGCGCGACTACGGGCTGCT
CGACTCGGCCTTGGCGCGTCCGCAGTCGAGCGTGTTCGGCCAGGACGCCTACCCGGACGTGTGGCAGAAGGCCGCGGCAC
TGATGGAGTCCCTCGCTCGCAACCATGCCCTCGTCGACGGGAACAAGCGCCTCGCCTGGTACGCGACCTGGGTCTTCCTG
CATATGAACGGGCATCCGCTCGACCCGGACTTCGACGTGGACGAGGCGGAGCAGTTCGTGCTGGACGTCTGCCAGGGCGC
ACTGGACGTCCCCAAGATCGCAGCTCAGTTGCCCCGCTTCGCGCGCTGA

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 11118.52 Da
• Isoelectric Point: 6.6439

>AT181798 WP_062773288.1 NZ_CP064828:c3741183-3740878 [Morganella morganii subsp. morganii]
MTKHTDEQHPVSGVNITRSTLNLRIKPEDKILIDRAAHAAGKNRTEFVLEAARRAAEETLADLRVIDVSTDVYQQFITRL
DMAPQSGEALHGHLSSATITG

Nucleotide

• Length: 306 bp

>AT181798 NZ_CP086174:c2966277-2966080 [Streptomyces fungicidicus]
ATGGCTGGACTGAACCTGCGGTTTACTGACGAAGAGCTCGATGCCCTGCGTGAGCGTGCGGCTGCGGAAGGGCGCAGCAT
GCAGACCTTCGCGCACGACGCGGTGATCAAGGCCATAAACGAACACTCGAGGCTGTTCAACGAGGCGGCCGACCACGTGC
TGAGGGCCAGCGAAGAGCTGAACCGGAGGCTCGCCTGA

Structures

Antitoxin

• AlphaFold DB: A0A447J977