Detailed information of TA system TA181796

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 1174179..1174840
• Replicon: chromosome
• Accession: NZ_CP064828
• Organism: Morganella morganii subsp. morganii strain ZJC25

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: S3IMJ6
• Locus tag: IZ183_RS05355
• Protein ID: WP_000698542.1
• Coordinates: 1174517..1174840 (+)
• Length: 108 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: S3J179
• Locus tag: IZ183_RS05350
• Protein ID: WP_000065326.1
• Coordinates: 1174179..1174496 (+)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IZ183_RS05305 (IZ183_05305)	1169319..1170143	+	825	WP_000197385.1	DUF932 domain-containing protein	-
IZ183_RS05310 (IZ183_05310)	1170352..1171062	+	711	WP_024198336.1	hypothetical protein	-
IZ183_RS05315 (IZ183_05315)	1171088..1171624	+	537	WP_000219797.1	DUF4339 domain-containing protein	-
IZ183_RS05320 (IZ183_05320)	1171666..1172103	+	438	WP_024198335.1	hypothetical protein	-
IZ183_RS05325 (IZ183_05325)	1172170..1172580	+	411	WP_000912997.1	hypothetical protein	-
IZ183_RS05330 (IZ183_05330)	1172658..1172894	+	237	WP_000004273.1	DUF905 domain-containing protein	-
IZ183_RS05335 (IZ183_05335)	1172980..1173438	+	459	WP_016538084.1	antirestriction protein	-
IZ183_RS05340 (IZ183_05340)	1173454..1173930	+	477	WP_000811694.1	RadC family protein	-
IZ183_RS05345 (IZ183_05345)	1173939..1174160	+	222	WP_000691995.1	DUF987 domain-containing protein	-
IZ183_RS05350 (IZ183_05350)	1174179..1174496	+	318	WP_000065326.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
IZ183_RS05355 (IZ183_05355)	1174517..1174840	+	324	WP_000698542.1	TA system toxin CbtA family protein	Toxin
IZ183_RS05360 (IZ183_05360)	1175676..1175783	+	108	WP_107678959.1	leader peptide SpeFL	-
IZ183_RS05365 (IZ183_05365)	1176163..1178325	+	2163	WP_015422912.1	ornithine decarboxylase SpeF	-
IZ183_RS05370 (IZ183_05370)	1178389..1179717	+	1329	WP_032098853.1	putrescine-ornithine antiporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1144680..1174840	30160

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-107)

Antitoxin

• Antitoxin CbeA (6-104)

Sequences

Toxin

Protein

• Length: 108 a.a.
• Molecular weight: 12350.38 Da
• Isoelectric Point: 8.9789

>T181796 WP_000698542.1 NZ_CP064828:1174517-1174840 [Morganella morganii subsp. morganii]
MKILPATISRAAKPCLPPVAVWQLLLTRLLEKHYGLTLNDTPFSDETVIKEHFDAGITLANAINFLVEKYELVRIDRRGF
SWQEQTPYLTNIDIMRARRDLGLLNRN

Nucleotide

• Length: 324 bp

>T181796 NZ_CP086173:3241776-3242042 [Streptomyces fungicidicus]
GTGAGTAGCGGCTACCGCACCGTCTTCCGGCCGGAGGCTCAGGCGGAGCTTCGCAAGATTCCCCGGGACATGGCCCTGAG
GATCCTGGTCAAACTGACGGAACTGGAAACGGACCCGCTCGGCTTCCGCACCACGGCGCTCGTCTCCCGGCCCGACCGGC
GCCGGCTCCGTGTCGGCGACTACCGCGTCATCTACACGATCGACAACGGCGAGTTGACGGTCTGGGTCGTTCATGTCGGA
CACCGCTCCACGGTATACGACACCTGA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11830.50 Da
• Isoelectric Point: 6.9367

>AT181796 WP_000065326.1 NZ_CP064828:1174179-1174496 [Morganella morganii subsp. morganii]
MSNIIWGLQRDITPRLGTRLVQEGNQLHYLADRACITGKFSDAECLKLDVAFPHFISRMESMLSTGEMNPRHAHCVTLYH
NGFTCEADTLGSCGYVYVAVYSTQR

Nucleotide

• Length: 318 bp

>AT181796 NZ_CP086173:3241517-3241783 [Streptomyces fungicidicus]
ATGACCGAGATGCCCATAGAGTCCATTCGTGACGTGCGCGCCCACCTGGCCGAGGTGGTCGAACGGGCGGACCGGGACGA
CACGCCCACGGTCATCACCCGGCGAGGCAAGCAGGTGGCCGCAGTCGTGTCGATGGAGGTCCTTCGCAAGTACCAGGAAT
GGGAAGAGCGCGAGATCAACCGGATCATCGACGAGCGCATGGCGAACCCGGCAGCCGGTATCCCGATCGAGGACGTCATG
CGGGAGACGCTGGAGCGCGGTGAGTAG

Structures

Toxin

• AlphaFold DB: S3IMJ6

Antitoxin

• AlphaFold DB: S3J179