Detailed information of TA system TA181795

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 932590..933073
• Replicon: chromosome
• Accession: NZ_CP064828
• Organism: Morganella morganii subsp. morganii strain ZJC25

Toxin (Protein)

• Gene name: relE
• Uniprot ID: J7TMG3
• Locus tag: IZ183_RS04220
• Protein ID: WP_004237651.1
• Coordinates: 932846..933073 (+)
• Length: 76 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: IZ183_RS04215
• Protein ID: WP_225310119.1
• Coordinates: 932590..932862 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IZ183_RS04210 (IZ183_04210)	927747..932381	+	4635	WP_062771823.1	hemagglutinin repeat-containing protein	-
IZ183_RS04215 (IZ183_04215)	932590..932862	+	273	WP_225310119.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
IZ183_RS04220 (IZ183_04220)	932846..933073	+	228	WP_004237651.1	type II toxin-antitoxin system YafQ family toxin	Toxin
IZ183_RS04225 (IZ183_04225)	933376..934860	+	1485	WP_004237652.1	C69 family dipeptidase	-
IZ183_RS04230 (IZ183_04230)	934926..935378	-	453	WP_004237653.1	NfeD family protein	-
IZ183_RS04235 (IZ183_04235)	935375..936313	-	939	WP_032099238.1	SPFH domain-containing protein	-
IZ183_RS04240 (IZ183_04240)	936369..937226	-	858	WP_015422944.1	co-chaperone YbbN	-
IZ183_RS04245 (IZ183_04245)	937286..938071	-	786	WP_062771820.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-74)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (2-78)

Sequences

Toxin

Protein

• Length: 76 a.a.
• Molecular weight: 9069.63 Da
• Isoelectric Point: 9.9416

>T181795 WP_004237651.1 NZ_CP064828:932846-933073 [Morganella morganii subsp. morganii]
MARTIERSSQFKKDYKREVKGIYRMMLNDSLQNILNILVNDLPIPEKYADHPLKGNWRTFRDCHLYPDLILIYKK

Nucleotide

• Length: 228 bp

>T181795 NZ_CP086173:c2966079-2965711 [Streptomyces fungicidicus]
ATGTACTACCTCACCTTGCCCGAGTTGCTGAACCTCGCGAAGCGGCTCGGGGAGGACGTGGTGCGCGACTACGGGCTGCT
CGACTCGGCCTTGGCGCGTCCGCAGTCGAGCGTGTTCGGCCAGGACGCCTACCCGGACGTGTGGCAGAAGGCCGCGGCAC
TGATGGAGTCCCTCGCTCGCAACCATGCCCTCGTCGACGGGAACAAGCGCCTCGCCTGGTACGCGACCTGGGTCTTCCTG
CATATGAACGGGCATCCGCTCGACCCGGACTTCGACGTGGACGAGGCGGAGCAGTTCGTGCTGGACGTCTGCCAGGGCGC
ACTGGACGTCCCCAAGATCGCAGCTCAGTTGCCCCGCTTCGCGCGCTGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10103.75 Da
• Isoelectric Point: 5.1746

>AT181795 WP_225310119.1 NZ_CP064828:932590-932862 [Morganella morganii subsp. morganii]
VEYVRAKIDPKLKAEAIETLESMGLTVSDAIRMLMIQIVEQKAMPFCVKSTQYRHAARIRAAIEELECGKGKKFDSISDL
MADLQDGKDD

Nucleotide

• Length: 273 bp

>AT181795 NZ_CP086173:c2966276-2966079 [Streptomyces fungicidicus]
ATGGCTGGACTGAACCTGCGGTTTACTGACGAAGAGCTCGATGCCCTGCGTGAGCGTGCGGCTGCGGAAGGGCGCAGCAT
GCAGACCTTCGCGCACGACGCGGTGATCAAGGCCATAAACGAACACTCGAGGCTGTTCAACGAGGCGGCCGACCACGTGC
TGAGGGCCAGCGAAGAGCTGAACCGGAGGCTCGCCTGA

Structures

Toxin

• AlphaFold DB: J7TMG3