Detailed information of TA system TA181793

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 3790493..3791145
• Replicon: chromosome
• Accession: NZ_CP064827
• Organism: Morganella morganii subsp. morganii strain ZJG944

Toxin (Protein)

• Gene name: TacT2
• Uniprot ID: -
• Locus tag: IZ186_RS18200
• Protein ID: WP_080939504.1
• Coordinates: 3790493..3790840 (-)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: TacA2
• Uniprot ID: -
• Locus tag: IZ186_RS18205
• Protein ID: WP_163654117.1
• Coordinates: 3790840..3791145 (-)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IZ186_RS18165 (IZ186_18175)	3785858..3786481	-	624	WP_004236525.1	thiol:disulfide interchange protein DsbA	-
IZ186_RS18170 (IZ186_18180)	3786500..3787495	-	996	WP_004236526.1	serine/threonine protein kinase	-
IZ186_RS18175 (IZ186_18185)	3787495..3787764	-	270	WP_004240741.1	YihD family protein	-
IZ186_RS19210	3787985..3788557	+	573	Protein_3545	molybdenum cofactor guanylyltransferase MobA	-
IZ186_RS19215	3788564..3789082	+	519	WP_225806429.1	molybdopterin-guanine dinucleotide biosynthesis protein MobB	-
IZ186_RS18185 (IZ186_18195)	3789292..3789594	+	303	WP_004236529.1	HdeA/HdeB family chaperone	-
IZ186_RS18190 (IZ186_18200)	3789722..3790243	+	522	WP_163654114.1	isopentenyl-diphosphate Delta-isomerase	-
IZ186_RS18195 (IZ186_18205)	3790240..3790485	+	246	WP_163652604.1	hypothetical protein	-
IZ186_RS18200 (IZ186_18210)	3790493..3790840	-	348	WP_080939504.1	GNAT family N-acetyltransferase	Toxin
IZ186_RS18205 (IZ186_18215)	3790840..3791145	-	306	WP_163654117.1	DUF1778 domain-containing protein	Antitoxin
IZ186_RS18210 (IZ186_18220)	3791277..3792629	-	1353	WP_004236534.1	glutathione-disulfide reductase	-
IZ186_RS18215 (IZ186_18225)	3792699..3793541	-	843	WP_036417394.1	23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ	-
IZ186_RS18220 (IZ186_18230)	3793731..3794120	+	390	WP_081119805.1	DUF1090 domain-containing protein	-
IZ186_RS18225 (IZ186_18235)	3794532..3795524	+	993	WP_049242212.1	inner membrane protein YhjD	-
IZ186_RS18230 (IZ186_18240)	3795632..3795838	+	207	WP_004236540.1	4-oxalocrotonate tautomerase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (28-90)

Antitoxin

• Vibrio phage ICP1, Orf50 (21-91)

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 12424.59 Da
• Isoelectric Point: 10.3028

>T181793 WP_080939504.1 NZ_CP064827:c3790840-3790493 [Morganella morganii subsp. morganii]
MAYYALSTGVITCSQAAGRFRRNMPPEIPVILPGRLAVDESVKGRGIGRGLIKDAALRVLQAAGIVGIRGIVVRALSDNA
RRFYEHTGFIPSPADPMLLMITLRDLQLATGIYSE

Nucleotide

• Length: 348 bp

>T181793 NZ_CP086141:218682-218939 [Clostridium estertheticum]
ATGAATAAGATTTTTTCAGAGGTATCATGGGAGCATTATGTATATTGGCAGTCAGAGGATAAAAAAATATTAAGAAAAAT
AAATGAACTTATAAAAGATATTGAAAGAAACGGAAATGAAGGTCTAGGAAAGCCTGAAGCATTAAAACATGAGTTGGTTG
GTTATTGGAGTCGAAGAATAACAGATGTTCATAGACTTATATATAGTATTGATGATGAGAATATCTATGTTGCAAGCTGC
AAAGGACATTATCACTAA

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 11146.57 Da
• Isoelectric Point: 6.6439

>AT181793 WP_163654117.1 NZ_CP064827:c3791145-3790840 [Morganella morganii subsp. morganii]
MTKHTDEQHPVSGVNITRSTLNLRIKPEDKILIDRAAHAAGKNRTEFVLEAARRAAEETLADLRVIDVSTDVYQQFITRL
DMAPQSGEALHGHLSSVTITG

Nucleotide

• Length: 306 bp

>AT181793 NZ_CP086141:218435-218689 [Clostridium estertheticum]
ATGATCGCTATAGGTTACTCGAACGCAAGACAAAATTTTAAAAATTATTGTGACAAAGCTACAAAAGATTTTGAAACCAT
TATTATTACTCGAGAGCGTGGTGACAACGTGGTTATGTTATCTGAATCGGCATATAATAACCTTATGGAAAATTTGTACG
TTAGAAGTGATCCCACCTATTATAATGAATTGCTGAAATCTATTGACCAATTAAAAATGGGAAAGGGAATTAGAAAGGAA
CTTCTTGATGAATAA