Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1008525..1009151 Replicon chromosome
Accession NZ_CP064827
Organism Morganella morganii subsp. morganii strain ZJG944

Toxin (Protein)


Gene name Hha Uniprot ID A0A0A2RCL2
Locus tag IZ186_RS04695 Protein ID WP_024474604.1
Coordinates 1008525..1008728 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J7U1S9
Locus tag IZ186_RS04700 Protein ID WP_004236473.1
Coordinates 1008792..1009151 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IZ186_RS04675 (IZ186_04685) 1005081..1005419 + 339 WP_004236467.1 P-II family nitrogen regulator -
IZ186_RS04680 (IZ186_04690) 1005439..1006728 + 1290 WP_112548198.1 ammonium transporter AmtB -
IZ186_RS04685 (IZ186_04695) 1006789..1007652 - 864 WP_004240378.1 acyl-CoA thioesterase II -
IZ186_RS04695 (IZ186_04705) 1008525..1008728 - 204 WP_024474604.1 HHA domain-containing protein Toxin
IZ186_RS04700 (IZ186_04710) 1008792..1009151 - 360 WP_004236473.1 Hha toxicity modulator TomB Antitoxin
IZ186_RS04705 (IZ186_04715) 1009714..1012890 - 3177 WP_015422956.1 efflux RND transporter permease subunit -
IZ186_RS04710 (IZ186_04720) 1012905..1014101 - 1197 WP_015422955.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-113)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8073.39 Da        Isoelectric Point: 6.9770

>T181792 WP_024474604.1 NZ_CP064827:c1008728-1008525 [Morganella morganii subsp. morganii]
MTKLDYLMRLRKCTSIETLERVIEKNKYELTDDELEVFYSAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

>T181792 NZ_CP086139:37689-38096 [Bradyrhizobium barranii subsp. barranii]
ATGTATCTCATTGATACCAACGTCGTTTCCGAGGCTCGGCGCGGCTCTCCGCAGGCAACCGGCTGGCTGCGCTCGGTGGA
TCCGGCCAGCGTCTACCTGAGCACCCTCACCCTCGGCGAGATCATGCGCGGCATCGCGCTGAAGCAGAAGTCGGACCCGA
AGGTGGCCGGCCACCTTGCCGAATGGTTGCGCAAGTTGCGCCACGACCACGCCAACCGCATCCTGGCGGTGACCGACCAG
ATCTCCGTCGAGTGGGGTCGCATCGCCGCGATCCGGCCGTGTGGCGATATCGACGGGCTGATCGCCGCAACCGCGATCGT
CCACGACCTCATCCTCGTCACCCGCAATGTGGGGGATTTCGAGGATACGGGTGCAACGGTAATCAATCCCTGGGAGGACT
CGGCATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13826.54 Da        Isoelectric Point: 4.2870

>AT181792 WP_004236473.1 NZ_CP064827:c1009151-1008792 [Morganella morganii subsp. morganii]
MDEYSPRNYDIAVLKYLCDELCREGTQTLIRSNNYWVNDLASDSNLKLNELLGYIADVAWSFKIKHTQNKDLISFVDEYI
DETYALFGQMEVSFNDVEEWKKMASLVSSMLTSEGHLVH

Download         Length: 360 bp

>AT181792 NZ_CP086139:37435-37689 [Bradyrhizobium barranii subsp. barranii]
ATGGAATGGCCGCTGCAGGACGCCAAGAACCAGTTTTCCAAGGTGGTGCAGAAGGCCCGCCTGGAAGGCCCGCAGGTCGT
CACCCTGCGCGGGATGCGCGCCGCGGTGGTGCTGTCGGCCGCCGATTACGATGCGCTGCGCTCCGGGCGGCCGACCTTGG
TCGACGACTTGCTGGCCGGGCCAAGCTGGGATGACGAACTGGCCGAAGAAGCGATGCGGCGCATCAAGCCCCCCAGCCGC
GACGCGGCCTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A2RCL2

Antitoxin

Source ID Structure
AlphaFold DB J7U1S9

References