Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 915852..916478 Replicon chromosome
Accession NZ_CP064826
Organism Morganella morganii subsp. morganii strain ZJD581

Toxin (Protein)


Gene name Hha Uniprot ID A0A0A2RCL2
Locus tag IZ187_RS04240 Protein ID WP_024474604.1
Coordinates 915852..916055 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0D8L953
Locus tag IZ187_RS04245 Protein ID WP_025151710.1
Coordinates 916119..916478 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IZ187_RS04220 (IZ187_04220) 912412..912750 + 339 WP_123568219.1 P-II family nitrogen regulator -
IZ187_RS04225 (IZ187_04225) 912770..914059 + 1290 WP_214221781.1 ammonium transporter AmtB -
IZ187_RS04230 (IZ187_04230) 914118..914981 - 864 WP_214221782.1 acyl-CoA thioesterase II -
IZ187_RS04240 (IZ187_04240) 915852..916055 - 204 WP_024474604.1 HHA domain-containing protein Toxin
IZ187_RS04245 (IZ187_04245) 916119..916478 - 360 WP_025151710.1 Hha toxicity modulator TomB Antitoxin
IZ187_RS04250 (IZ187_04250) 917040..920216 - 3177 WP_186849036.1 efflux RND transporter permease subunit -
IZ187_RS04255 (IZ187_04255) 920231..921427 - 1197 WP_205515748.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-113)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8073.39 Da        Isoelectric Point: 6.9770

>T181788 WP_024474604.1 NZ_CP064826:c916055-915852 [Morganella morganii subsp. morganii]
MTKLDYLMRLRKCTSIETLERVIEKNKYELTDDELEVFYSAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

>T181788 NZ_CP086137:c92407-92069 [Bradyrhizobium barranii subsp. barranii]
ATGCCAGCCTTTAAGCAGGGTGACGTCGTTAGGGTTCCTTTCCCGTACACTGATCGATCAACTCGTCAGCATCGCCCGGC
ACTCGTTGTATCCACAGGAGGCATCGGGGAAAATGGAAACCTTCTTTGGGTGGTGATGATCACGAGTGCTGAAAACAGAA
CATGGCCCGGGGATATTGCAATCAGTCGCTACGAAGAGGCCGGTCTGCCTGCTCCCTCCATCATTCGACCTTGTAAGATA
GCGACGATAGAGGCGCGCGACGCGGAACGGCTCGGTCGCATCAAGCCTCGTTTGATGATCGAAGTTTTATCAGAGATGCG
CGGCATTCTGGGTAGCTGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13856.57 Da        Isoelectric Point: 4.2870

>AT181788 WP_025151710.1 NZ_CP064826:c916478-916119 [Morganella morganii subsp. morganii]
MDEYSPRNYDIAVLKYLCDELCREGTQTLIRSNNYWVNDLASDSNLKLNELLGYIADVTWSFKIKHTQNKDLISFVDEYI
DETYALFGQMEVSFNDVEEWKKMASLVSSMLTSEGHLVH

Download         Length: 360 bp

>AT181788 NZ_CP086137:c92609-92394 [Bradyrhizobium barranii subsp. barranii]
ATGATTACGAGTAAACTGACTACCAAAGCTCAAACCACGATCCCCCAGGCAGTCCGAACCGCTCTGCATCTGAAGGAAGG
TGATGAGATCGCTTATACGATCACTGGTGATAAGGTCGTGCTGACAAAGGCTGAACCTGCTCTGGTCGATGATCCCTTCG
TCACCTTCAGCGAATGGGACAGCGAGGCAGATCGGAAAGCCTATGCCAGCCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A2RCL2

Antitoxin

Source ID Structure
AlphaFold DB A0A0D8L953

References