Detailed information of TA system TA181739

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-yefM/YoeB-RelB
• Location: 1778358..1778868
• Replicon: chromosome
• Accession: NZ_CP064795
• Organism: Salinimonas sp. G2-b

Toxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: IT774_RS07880
• Protein ID: WP_195812084.1
• Coordinates: 1778605..1778868 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A7S9HEL5
• Locus tag: IT774_RS07875
• Protein ID: WP_018982647.1
• Coordinates: 1778358..1778612 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IT774_RS07855	1773950..1775752	+	1803	WP_195812081.1	ThiF family adenylyltransferase	-
IT774_RS07860	1775742..1776224	+	483	WP_195812082.1	Mov34/MPN/PAD-1 family protein	-
IT774_RS07865	1776415..1777386	-	972	WP_195812083.1	integron integrase	-
IT774_RS07870	1777823..1778164	+	342	WP_195812238.1	hypothetical protein	-
IT774_RS07875	1778358..1778612	+	255	WP_018982647.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
IT774_RS07880	1778605..1778868	+	264	WP_195812084.1	Txe/YoeB family addiction module toxin	Toxin
IT774_RS07885	1779260..1781458	-	2199	WP_195812085.1	DEAD/DEAH box helicase	-
IT774_RS07890	1781455..1782762	-	1308	WP_195812086.1	ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1767900..1791186	23286

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10343.69 Da
• Isoelectric Point: 9.4238

>T181739 WP_195812084.1 NZ_CP064795:1778605-1778868 [Salinimonas sp. G2-b]
MSNRLLSWTDEAWNSYVYWQTQDKKTLRRINKLISDVKRSPFDGIGKPEPLKENLSGFWSRRIDDTNRLVYAVDDTAITV
ISCRYHY

Nucleotide

• Length: 264 bp

>T181739 NZ_CP086118:c1028556-1028029 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCGGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9494.70 Da
• Isoelectric Point: 5.0623

>AT181739 WP_018982647.1 NZ_CP064795:1778358-1778612 [Salinimonas sp. G2-b]
MRIVSFTEARNGLKAVLDNVINDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPANAEHLNRSIAQFKAAKTTQRE
LIDE

Nucleotide

• Length: 255 bp

>AT181739 NZ_CP086118:c1028843-1028553 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACATACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTAAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A7S9HEL5