Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4986665..4987322 Replicon chromosome
Accession NZ_CP064784
Organism Klebsiella sp. BDA134-6

Toxin (Protein)


Gene name cptA Uniprot ID H3N294
Locus tag IYV58_RS23010 Protein ID WP_004124948.1
Coordinates 4986665..4987075 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID H3N295
Locus tag IYV58_RS23015 Protein ID WP_004124953.1
Coordinates 4987056..4987322 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IYV58_RS22990 4982642..4984375 - 1734 WP_004124937.1 single-stranded-DNA-specific exonuclease RecJ -
IYV58_RS22995 4984381..4985094 - 714 WP_049115165.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
IYV58_RS23000 4985117..4986013 - 897 WP_004124942.1 site-specific tyrosine recombinase XerD -
IYV58_RS23005 4986135..4986656 + 522 WP_195729283.1 flavodoxin FldB -
IYV58_RS23010 4986665..4987075 - 411 WP_004124948.1 protein YgfX Toxin
IYV58_RS23015 4987056..4987322 - 267 WP_004124953.1 FAD assembly factor SdhE Antitoxin
IYV58_RS23020 4987567..4988550 + 984 WP_004124956.1 tRNA-modifying protein YgfZ -
IYV58_RS23025 4988723..4991521 + 2799 WP_004124960.1 transcriptional regulator DagR -
IYV58_RS23030 4991642..4992067 + 426 WP_004124962.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16089.88 Da        Isoelectric Point: 10.9455

>T181733 WP_004124948.1 NZ_CP064784:c4987075-4986665 [Klebsiella sp. BDA134-6]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLVLPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWDIIGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLQKPTQE

Download         Length: 411 bp

>T181733 NZ_CP086113:143394-143729 [Skermanella rosea]
GTGAGGCGTGGCGATCTGGTCACCATCGCTGGCCGGATCGGCGGCGATTATGACGGCAAACCCCGGCCCGCGGTGATCAT
CCAGTCCGACGATTTTCCGGACACCGACAGCGTCACCGTTTCGCTGCTGACCTCCATCGGCATCGACGCCCCACTGCTGA
GACTGCGCATCGACCCGGCGCCGGCCAACAACCTTCGCCAGACCTCCTGGGTCATGATCGACAAGATCGCGACCGTCAGG
CGAAGAAACATAAGGGCCGTGTTCGGCCGCTTGAGCGATGCCGAACTGGTCCAGGTCAACCGCGCCTTGCCGGTGTTTCT
CGGGATCGCGGGGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10411.88 Da        Isoelectric Point: 5.1296

>AT181733 WP_004124953.1 NZ_CP064784:c4987322-4987056 [Klebsiella sp. BDA134-6]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDGDKALFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT181733 NZ_CP086113:143173-143397 [Skermanella rosea]
ATGCCTTCGACCGTCCGTCACCGTGTCCAGACCCACCGGGCGCAGCTTCGCGCGCAGGGACTGAGGCCGATCCAGATCTG
GGTGCCGGATGTCCGCTCCCCCACGTTCAAGGAAGAGGCGCGGCGGCAGTCCCGTGCCGTTGCCGCCGCACCCGACGAAG
CCGACACCATGGACTTCCTGGAGGATATCCAGGATCTTGGCGATGATGTCGGCGACAGGCCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H3N294

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3H3L9

References