Detailed information of TA system TA181706

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 2430678..2431454
• Replicon: chromosome
• Accession: NZ_CP064772
• Organism: Staphylococcus aureus strain TCH32767

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: X5E2E6
• Locus tag: IXH55_RS12000
• Protein ID: WP_000031108.1
• Coordinates: 2431302..2431454 (+)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: IXH55_RS11995
• Protein ID: WP_001251224.1
• Coordinates: 2430678..2431277 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IXH55_RS11975 (IXH55_11910)	2426594..2428051	+	1458	WP_000649908.1	ABC transporter permease subunit	-
IXH55_RS11980 (IXH55_11915)	2428044..2428766	+	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
IXH55_RS11985 (IXH55_11920)	2428917..2430044	+	1128	WP_000379980.1	tRNA epoxyqueuosine(34) reductase QueG	-
IXH55_RS11990 (IXH55_11925)	2430049..2430519	+	471	WP_000181395.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
IXH55_RS11995 (IXH55_11930)	2430678..2431277	+	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
IXH55_RS12000 (IXH55_11935)	2431302..2431454	+	153	WP_000031108.1	SAS053 family protein	Toxin
IXH55_RS12005 (IXH55_11940)	2432002..2432397	+	396	WP_000901023.1	hypothetical protein	-
IXH55_RS12010 (IXH55_11945)	2432593..2433978	+	1386	WP_000116228.1	class II fumarate hydratase	-
IXH55_RS12015 (IXH55_11950)	2434431..2435252	-	822	WP_000669376.1	RluA family pseudouridine synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5936.28 Da
• Isoelectric Point: 3.8962

>T181706 WP_000031108.1 NZ_CP064772:2431302-2431454 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T181706 NZ_CP086104:2825776-2826189 [Ralstonia sp. RS650]
TTGAGTTACCTGATCGACACCAATGTCCTGTCCGAATTGCGCCGCAAAGCGCCCGATGCGCGCGTGGTGGCCTGGATGCA
GGACCGCCCGCGCCAGTCGCTCTACCTGAGCGTGCTGACCCTGGGCGAGATTCGCAAAGGTATCGAGCGGCTGGACGACG
CGGCGCGCCGCCAGCACCTGATTGACTGGCTCGAAGTGGAACTGCCGAACTACTTTCTCGGCCGATTGCTCGACATCGAT
GCGCATACCGCCGACCGCTGGGGCCGGCTGATGTCCTCGGCCGGCCGCCCCCTGCCCGCCATCGACGGCCTGCTGGCCGC
GACCGCCCTGCAACACGACCTCACGCTGGTCACGCGCAACACCAAGGATTTCGCGGGGCTCGACGTCCAGCTCATCAACC
CATGGGAAGCCTGA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT181706 WP_001251224.1 NZ_CP064772:2430678-2431277 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT181706 NZ_CP086104:2825528-2825779 [Ralstonia sp. RS650]
ATGCAAAGCTGGCAAATGCAGGCCGCCAAGGCGCGGTTTTCCGATGTCGTGAAGCGGGCGGCAGACGATGGCCCGCAGGA
AATCACCGTGCATGGCCGCCCGGTGGCGGTGGTGATCTCGCGCGCACTGTTCGATCGCTTGAGCGGCGGCGGTGAGTCGC
TGGTCAGCTTCATGCGCCAATCCCCGCTGGCCGACCAGGACGATGTCGTCTTTGAGCGCGAGCGCAGCCTGCCGCGCGAG
GTCGAGTTTTGA

Structures

Toxin

• AlphaFold DB: X5E2E6

Antitoxin

• AlphaFold DB: W8U4V4