Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2256594..2257108 Replicon chromosome
Accession NZ_CP064772
Organism Staphylococcus aureus strain TCH32767

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag IXH55_RS11010 Protein ID WP_000581792.1
Coordinates 2256899..2257108 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag IXH55_RS11005 Protein ID WP_000138932.1
Coordinates 2256594..2256887 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IXH55_RS10985 (IXH55_10930) 2251857..2252498 + 642 WP_000483153.1 thiamine phosphate synthase -
IXH55_RS10990 (IXH55_10935) 2252584..2253456 + 873 WP_000725802.1 membrane protein insertase YidC -
IXH55_RS10995 (IXH55_10940) 2254269..2254916 - 648 WP_001187630.1 HD domain-containing protein -
IXH55_RS11000 (IXH55_10945) 2254944..2256428 - 1485 WP_000571549.1 cardiolipin synthase -
IXH55_RS11005 (IXH55_10950) 2256594..2256887 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
IXH55_RS11010 (IXH55_10955) 2256899..2257108 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
IXH55_RS11015 (IXH55_10960) 2257236..2257373 + 138 WP_000828354.1 Lmo0850 family protein -
IXH55_RS11020 (IXH55_10965) 2257637..2258839 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
IXH55_RS11025 (IXH55_10970) 2259157..2260227 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
IXH55_RS11030 (IXH55_10975) 2260242..2261600 + 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T181704 WP_000581792.1 NZ_CP064772:2256899-2257108 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T181704 NZ_CP086104:505800-506213 [Ralstonia sp. RS650]
ATGCCCGCGACTGAGGCATTCTTCGACAGCAATGTCGTGCTGTACCTGCTGTCGGCCGACACCGCCAAGGCCGATGCGGC
GGAAACGCTGCTGATGACCGGCGGTGTCGTCAGCGTACAGGTACTGAACGAAACGACGCACGTAATGCGCCGCAAGCTGG
CCATGCCGTGGCACGCGATCGAAACGGTGCAGGAGGCCGTGCGTGCGCAATGCCGGGTCGAGCCGCTGACGCTCGAAACC
CATGATCTCGGACGGCGTATCGCAGAACGCTACGGATTGTCGGTCTATGACGCACTGATCGTCGCGGCGGCATTGCTTGC
CGGCTGCAACGTTCTGTATTCCGAGGATATGCAGCACGGCCTGGTGATCGAGCAGCATCTGCGCATCGTCAATCCTTTTC
CGGCACGGGCATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT181704 WP_000138932.1 NZ_CP064772:2256594-2256887 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT181704 NZ_CP086104:505580-505813 [Ralstonia sp. RS650]
ATGCAAGTCTCGAAATGGGGCAACAGCCTCGCTATCCGGCTGCCGGCGGCCGTTGTGGAGGCGCTTCAGCTGCACGAAGG
CGACGACGTCGAGGTGGTGATCGCGGGCGAGCGCTCGTTTGGCGTCCGCCGCAAGCGCGCTGCGCGCGAGCTTTTCGACC
GGATCCACCAATATCGCGGCAAGCTGCCCGCCGATTTCATCTTCGAGCGCGACCAGGCCAATGCCCGCGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References