181696

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 1882996..1883519 Replicon chromosome
Accession NZ_CP064772
Organism Staphylococcus aureus strain TCH32767

Toxin (Protein)


Gene name relE Uniprot ID A0A3A5LQI3
Locus tag IXH55_RS09065 Protein ID WP_000074049.1
Coordinates 1883253..1883519 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag IXH55_RS09060 Protein ID WP_000587616.1
Coordinates 1882996..1883253 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IXH55_RS09045 (IXH55_09000) 1879493..1880242 - 750 WP_000072461.1 CPBP family lipoprotein N-acylation protein LnsB -
IXH55_RS09050 (IXH55_09005) 1880437..1882014 + 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
IXH55_RS09055 (IXH55_09010) 1882182..1882637 - 456 WP_000732076.1 DUF1307 domain-containing protein -
IXH55_RS09060 (IXH55_09015) 1882996..1883253 + 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IXH55_RS09065 (IXH55_09020) 1883253..1883519 + 267 WP_000074049.1 Txe/YoeB family addiction module toxin Toxin
IXH55_RS09070 (IXH55_09025) 1883874..1884950 + 1077 WP_001076673.1 M42 family metallopeptidase -
IXH55_RS09075 (IXH55_09030) 1885198..1885860 + 663 WP_000923526.1 ATP-binding cassette domain-containing protein -
IXH55_RS09080 (IXH55_09035) 1885853..1886629 + 777 WP_000072149.1 iron export ABC transporter permease subunit FetB -
IXH55_RS09085 (IXH55_09040) 1887025..1888212 + 1188 WP_000026189.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10676.24 Da        Isoelectric Point: 10.1597

>T181696 WP_000074049.1 NZ_CP064772:1883253-1883519 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T181696 NZ_CP086101:477553-477837 [Enterobacter ludwigii]
ATGAGTTATGAACTCGTATTTGATCCGAGGGCGTTCAAGGAGTGGACCAGGCCGGGTGATACCGTAAAAAATCAGTTTAA
GAAGAAGCTTGCGAACGTGTTGGTGAACCCCTGGGTTGAATCGGCTCGCCTGCATGGCCTGCCTGATTGCGACAAGATAA
AACTCAGATCCCAGGGTTATCGTTTGGTCTATCAGGTTCAGGACAATGTTGTGACGGTATGTGTTATTACTATCGGTAAG
AGAGAGAAATCAGCCGTTTATCATGACGTAAACAAACGGCTTTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT181696 WP_000587616.1 NZ_CP064772:1882996-1883253 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT181696 NZ_CP086101:477321-477563 [Enterobacter ludwigii]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAACGAGGCTTATGCCGTGCTTGAAAAACTCAATATCACGCC
AACGGAAGCCGTTCGGTTACTGTTTCAGTACGTTGCGGAGACGGGGCATATGCCGGTGAAAATGGTCACTGTTAGCGACA
GTGAAGATGAACTCATACAGACAGTCCGGGAGCGGCTGGCTAATCCGCAAAAAGGAATTAAGGTTAGGCTGGATGAGTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A5LQI3

Antitoxin

Source ID Structure
AlphaFold DB W8TQT5

References