Detailed information of TA system TA181695

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 729530..730007
• Replicon: chromosome
• Accession: NZ_CP064772
• Organism: Staphylococcus aureus strain TCH32767

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: IXH55_RS03595
• Protein ID: WP_000052076.1
• Coordinates: 729819..730007 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: IXH55_RS03590
• Protein ID: WP_001059690.1
• Coordinates: 729530..729790 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IXH55_RS03555 (IXH55_03525)	724923..725639	-	717	WP_000150011.1	type I 3-dehydroquinate dehydratase	-
IXH55_RS03560 (IXH55_03530)	725787..726209	+	423	WP_000974460.1	organic hydroperoxide resistance protein	-
IXH55_RS03565 (IXH55_03535)	726608..727102	+	495	WP_000569883.1	GNAT family N-acetyltransferase	-
IXH55_RS03570 (IXH55_03540)	727257..727874	+	618	WP_000255551.1	LysE/ArgO family amino acid transporter	-
IXH55_RS03575 (IXH55_03545)	727947..728528	-	582	WP_001140693.1	histidine phosphatase family protein	-
IXH55_RS03580 (IXH55_03550)	728753..728989	+	237	WP_000349581.1	hypothetical protein	-
IXH55_RS03585 (IXH55_03555)	728986..729189	-	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
IXH55_RS03590 (IXH55_03560)	729530..729790	+	261	WP_001059690.1	hypothetical protein	Antitoxin
IXH55_RS03595 (IXH55_03565)	729819..730007	+	189	WP_000052076.1	hypothetical protein	Toxin
IXH55_RS03600 (IXH55_03570)	730195..730764	+	570	WP_001106658.1	lipoprotein N-acylation protein LnsA	-
IXH55_RS03605 (IXH55_03575)	730852..731121	+	270	WP_001004398.1	hypothetical protein	-
IXH55_RS03610 (IXH55_03580)	731198..731416	+	219	WP_000005886.1	hypothetical protein	-
IXH55_RS03615 (IXH55_03585)	731908..732108	-	201	WP_001059082.1	cold-shock protein	-
IXH55_RS03620 (IXH55_03590)	732465..733151	-	687	WP_000141557.1	thermonuclease family protein	-
IXH55_RS03625 (IXH55_03595)	733492..734013	-	522	WP_244777081.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T181695 WP_000052076.1 NZ_CP064772:729819-730007 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T181695 NZ_CP086100:c3884764-3884354 [Enterobacter ludwigii]
GTGGTCCTGTGGCAATCTGACCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCGTTGTTGCTCCACGGCCTGGTCGCGGC
CTTTGTGTTACTGATGCCGTGGCCGCTTAGCTATACGCCTCTGTGGCTGCTGTTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGCCGCATTCATGCCCGTCAGGGGGAGATCAAATTACTGATGGATTCCCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAAATTCTCGGTATGCCCTGGATGATCGCTTCCGGCATGATGCTGCGGCTACGTAGCGTGGACAGCGGGCGTCG
CCAGCATCTGTGGCTGGCCGCGGACAGTATGGATAGCGCTGAGTGGCGAGACCTGCGTCGGATGTTATTACAGCAGCTGA
CGCAGGAGTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT181695 WP_001059690.1 NZ_CP064772:729530-729790 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT181695 NZ_CP086100:c3885011-3884745 [Enterobacter ludwigii]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACAGCTTAAGCGATGATGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCTGATT
TATTTAACTGGCTGATGAATCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56