Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4835438..4835954 Replicon chromosome
Accession NZ_CP064768
Organism Klebsiella pneumoniae subsp. pneumoniae strain HS20R14

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag HS20R14_RS23325 Protein ID WP_004178374.1
Coordinates 4835438..4835722 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag HS20R14_RS23330 Protein ID WP_002886901.1
Coordinates 4835712..4835954 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HS20R14_RS23300 (4830922) 4830922..4831185 - 264 WP_020324507.1 PTS system, lactose/cellobiose-specific IIB subunit -
HS20R14_RS23305 (4831315) 4831315..4831488 + 174 WP_032408826.1 hypothetical protein -
HS20R14_RS23310 (4831491) 4831491..4832234 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
HS20R14_RS23315 (4832591) 4832591..4834729 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
HS20R14_RS23320 (4834970) 4834970..4835434 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HS20R14_RS23325 (4835438) 4835438..4835722 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HS20R14_RS23330 (4835712) 4835712..4835954 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HS20R14_RS23335 (4836032) 4836032..4837942 - 1911 WP_004178373.1 PRD domain-containing protein -
HS20R14_RS23340 (4837965) 4837965..4839119 - 1155 WP_004178372.1 lactonase family protein -
HS20R14_RS23345 (4839186) 4839186..4839926 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T181687 WP_004178374.1 NZ_CP064768:c4835722-4835438 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T181687 NZ_CP086071:120779-121156 [Rhodococcus pyridinivorans]
GTGACGTTCTACCTCGATCGCGACGATCTCCTCACGATCGCGGCGCGTGTCAACGGCGGGTCACCCACTGTGCGCGAGAT
GGGCCTGCTCGACGCGGCGATCGCGCGCCCGCAGAGCACGGTGTTTGGTGTCGACGCCTATCCCACACTGTTCGAGAAGG
CAGCTGCGCTGCTTCACTCCATCGCCCGAAATCACGCTCTCGTCGATGGCAACAAGCGGACCGCTTGGGCGGCGACATGG
CTGTTTCTCGGTTACAACGGTATCCGTCTGCGCCGCGGCTTCGACGTCGATTCTGCTGAGGCGCTGGTGAATGACACGGC
CACGGGCGCTCACGACGTCACCTCGATCGCCGCAGCTCTCGCGACGTTCGTGGCCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT181687 WP_002886901.1 NZ_CP064768:c4835954-4835712 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT181687 NZ_CP086071:120585-120782 [Rhodococcus pyridinivorans]
ATGCCCGGACTCAACATTCAGTTCACCGACGACGAGCAGGCGCTGATCCGCGACGCCGCCGAACGCGAGGGGGTCTCCCT
CAAAGCGTTCGTGCACAACGCCTCGCTCGACGCTGCCAGTAGCCGTAAGCGCCTGCGCAGCGAACTGCTCGCCGACATCT
TCGACAAGTCGGCTGAACTCAATGCGCGACTCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References