Detailed information of TA system TA181670

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2510096..2510763
• Replicon: chromosome
• Accession: NZ_CP064761
• Organism: Companilactobacillus futsaii strain Chongqingii CQ16Z1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: IT773_RS12200
• Protein ID: WP_195701506.1
• Coordinates: 2510581..2510763 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: IT773_RS12195
• Protein ID: WP_195701505.1
• Coordinates: 2510096..2510551 (-)
• Length: 152 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IT773_RS12180	2505806..2507257	-	1452	WP_149029846.1	IS1182 family transposase	-
IT773_RS12185	2507421..2508830	-	1410	WP_195701504.1	SLAP domain-containing protein	-
IT773_RS12190	2509076..2509996	+	921	WP_149029770.1	IS30 family transposase	-
IT773_RS12195	2510096..2510551	-	456	WP_195701505.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
IT773_RS12200	2510581..2510763	-	183	WP_195701506.1	type II toxin-antitoxin system HicA family toxin	Toxin
IT773_RS12205	2510960..2511289	-	330	WP_195702110.1	metal-sulfur cluster assembly factor	-
IT773_RS12210	2511294..2512685	-	1392	WP_195701507.1	Fe-S cluster assembly protein SufB	-
IT773_RS12215	2512678..2513124	-	447	WP_195701508.1	SUF system NifU family Fe-S cluster assembly protein	-
IT773_RS12220	2513121..2514350	-	1230	WP_195701509.1	cysteine desulfurase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2514541..2515896	1355

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-59)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6674.05 Da
• Isoelectric Point: 11.2565

>T181670 WP_195701506.1 NZ_CP064761:c2510763-2510581 [Companilactobacillus futsaii]
MPMTQKEMVKLLKTNGWAKTIGGKGSHIKMSKLGKRPITVPHGELNKFTERAIKKEAGLK

Nucleotide

• Length: 183 bp

>T181670 NZ_CP086061:c3650835-3650485 [Bacillus sp. BC1-43]
TTGATTGTGAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGGGTGCGCCCGGT
TTTAGTGATCCAAAATGACATCGGAAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCACAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATCGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGGTTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin

Protein

• Length: 152 a.a.
• Molecular weight: 16994.32 Da
• Isoelectric Point: 4.9202

>AT181670 WP_195701505.1 NZ_CP064761:c2510551-2510096 [Companilactobacillus futsaii]
MLVSYPALFYYDQSEKVPFFITFPDFTNSGTQGNDVTDAMSMATDWLGINVADYLENNRPLPAPSTLEEISLAKNNPYPE
DLKYDSKRSFKSMVLVDLDSYLKGDIKIKKTVSIPKWADRAGADLHINYSATLTEAIAQAKMLHDSKIMNK

Nucleotide

• Length: 456 bp

>AT181670 NZ_CP086061:c3651121-3650840 [Bacillus sp. BC1-43]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACCTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGAACAACTCGTCACAACC
GTGATTTGATGAGACGCGGCTATATGGAAATGGCGAAAATCAACCTGAATATTTCTTCTGAGGCTCACTTTGCGGAGTGC
GAGGCTGAAACGACAGTTGAGCGCTTAGTCAGCGGAGGATAA