Detailed information of TA system TA181663

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-yefM/YoeB-YefM
• Location: 518512..519047
• Replicon: chromosome
• Accession: NZ_CP064760
• Organism: Microbacterium schleiferi strain A32-1

Toxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: IT882_RS02545
• Protein ID: WP_195693037.1
• Coordinates: 518787..519047 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: IT882_RS02540
• Protein ID: WP_195693036.1
• Coordinates: 518512..518790 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IT882_RS02500	513723..514547	-	825	WP_195693029.1	sugar phosphate isomerase/epimerase	-
IT882_RS02505	514691..515911	+	1221	WP_195693030.1	ROK family protein	-
IT882_RS02510	516178..516383	-	206	Protein_493	fatty acid desaturase	-
IT882_RS02515	516638..517036	-	399	WP_195693031.1	type II toxin-antitoxin system VapC family toxin	-
IT882_RS02520	517033..517287	-	255	WP_195693032.1	type II toxin-antitoxin system VapB family antitoxin	-
IT882_RS02525	517359..517601	+	243	WP_195693033.1	ribbon-helix-helix domain-containing protein	-
IT882_RS02530	517598..518035	+	438	WP_195693034.1	type II toxin-antitoxin system VapC family toxin	-
IT882_RS02535	518185..518472	+	288	WP_195693035.1	hypothetical protein	-
IT882_RS02540	518512..518790	+	279	WP_195693036.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
IT882_RS02545	518787..519047	+	261	WP_195693037.1	Txe/YoeB family addiction module toxin	Toxin
IT882_RS02550	519270..520766	+	1497	WP_195693038.1	plasmid pRiA4b ORF-3 family protein	-
IT882_RS02555	520930..521262	+	333	WP_195693039.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (7-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (12-82)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10242.60 Da
• Isoelectric Point: 8.4613

>T181663 WP_195693037.1 NZ_CP064760:518787-519047 [Microbacterium schleiferi]
VTRALVFDPNGWEDYLYWQTQDRKTLKRINTLIAAVLRDPFDGVGKPEQLRHVLSGSWSRRIDEKNRLVYYVTDDHIVIL
QARDHY

Nucleotide

• Length: 261 bp

>T181663 NZ_CP086023:2657473-2658156 [Paracidovorax citrulli]
ATCTTCAAACGCTCGCTCGCAGAAACTCCAGAGGGAGCAAAACTTACCTCGGCGCAGGTACACGCCGAGTCGTGCATCCT
CGCTGACCGGCTTGAAGACGAACTCCGATTGCAGAAGACCGCGAGCGGCGCGGCGATCAGCATGCTGGTCGATAAGCGAC
TGGCTGGAGCGCACGAAATCGACGCGTACATCAAGCTGGCTCAGGAGACCGGTCGCAAAATCGAGTTGTGCGATATTGAT
GCTCCACTCGAGCAGTCACTCATGGGCGTGCTGCAGCGCAAGCCCGAAGGTGACGCCCCCCGGCCACCCTACGTTGCGGT
TGCCAACGGATTCTCGGCGGTTCGCGGGCACCGGCTCGATGTCATCGACAAGTTTCTCTCGAACCCGACCTTGGGGAGCT
ATCATCTATTCGGCACTACCGGGAATGGCAGCAAGGCGATGGTTGCCAGCGTCGTCAACGGTGAACTGAGCATTCATGAC
CCTCAGTTATACGAGGCCATTACAGATCCCCAAGGTGCCCGGGCAGGCGATAGCGGCGATCAGATCATTGACGCTGCGCT
GATCGACCGGCTGACCAAAGGTATAGACGACCCAGCGCGAGCCATGGATGCCCGCACCGCATTGGAGCGGTACGCGGGCA
TGACGTGGTCGGACGCTCTGGCCGCCCATAGTTCACTGACTTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10214.35 Da
• Isoelectric Point: 4.8259

>AT181663 WP_195693036.1 NZ_CP064760:518512-518790 [Microbacterium schleiferi]
MYHSSGGVPVSAITATEARKSLFGLIQQVNDDHTTVEVVSRRGNAVIMSKDDYDALTETAYLLRNPANAERLLEAVERAR
RGEFEQHDLVDP

Nucleotide

• Length: 279 bp

>AT181663 NZ_CP086023:2658171-2658467 [Paracidovorax citrulli]
ATGACAGGCCTGAAAGGCGCAGATGCGCTCGACTTCCATAAGAAACTCAAGGAACGCAATGCTGCTTTACGCAATGCGGA
GTTGAACGCGGCGAAGGAACTGGCCGACAAAAATGGCAAGGAGCCTTTTGATCTAGTGAAACTGGAGAGGCTTTGCGATA
CCAGTCAAGCAGGCCGCCTTGTTGAAGGGACCGAACGGCAAGCCATGTACGAATACATGTACTACGTCGAGTACAAGAAT
GTTGGCACGTTGCAGGATTTCGCCCGGGTGGTGACAACACTCGCGTCCTGGTCTTAG