Detailed information of TA system TA181659

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 4728198..4729771
• Replicon: chromosome
• Accession: NZ_CP064746
• Organism: Aeromonas bestiarum strain YK48

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: IU367_RS21930
• Protein ID: WP_274453099.1
• Coordinates: 4728198..4729517 (-)
• Length: 440 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: IU367_RS21935
• Protein ID: WP_274453100.1
• Coordinates: 4729517..4729771 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IU367_RS21915 (IU367_21780)	4724096..4724860	+	765	WP_274453096.1	ATP-binding cassette domain-containing protein	-
IU367_RS21920 (IU367_21785)	4724879..4725799	+	921	WP_274453097.1	ABC transporter substrate-binding protein	-
IU367_RS21925 (IU367_21790)	4725796..4727778	+	1983	WP_274453098.1	Fe(3+)-hydroxamate ABC transporter permease FhuB	-
IU367_RS21930 (IU367_21795)	4728198..4729517	-	1320	WP_274453099.1	type II toxin-antitoxin system HipA family toxin	Toxin
IU367_RS21935 (IU367_21800)	4729517..4729771	-	255	WP_274453100.1	helix-turn-helix domain-containing protein	Antitoxin
IU367_RS21940 (IU367_21805)	4730679..4731302	+	624	WP_042878565.1	recombinase family protein	-
IU367_RS21945 (IU367_21810)	4731843..4732592	-	750	WP_274453101.1	SprT family zinc-dependent metalloprotease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-104)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 440 a.a.
• Molecular weight: 49442.44 Da
• Isoelectric Point: 7.0148

>T181659 WP_274453099.1 NZ_CP064746:c4729517-4728198 [Aeromonas bestiarum]
MANLAVYMNGYRVGTFTKTTSGAHQFQYHGSWLAQPGSRPISLSMPLRHQAYRGDEAYNFFDNLLPDNTEVRNRVVARYQ
AVSTQPFDLLSCIGQDSVGALQLVTEGHDVPDVRRIDYKALSDDELEQILTSYKSGIPLGMVREQEEFRISIAGAQEKTA
LLYLDGRWYLPLNATPTTHIIKLPIGKIESHSYSIDLSQSVENEYICTLIAKEFSLPVPHCFMMQVGQVKALAVERFDRR
YATDRSWIMRLPQEDFCQVLNVPSARKYESHGGPGITDIMKTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSVYPVFGGRGLNRRDAKLAMGLASSKGKKYAIEQIFPRHFFQTAKAVGFERSAMEEILTELANSV
DDVIERVTQQLPAGFPDAISSSILEGLKARSARLIKGWD

Nucleotide

• Length: 1320 bp

>T181659 NZ_CP086018:533217-533630 [Ralstonia sp. RS642]
ATGCCCGCGACTGAGGCATTCTTCGACAGCAATGTCGTGCTGTACCTGCTGTCGGCCGACACCGCCAAGGCCGATGCGGC
GGAAACGCTGCTGATGACCGGCGGTGTCGTCAGCGTACAGGTACTGAACGAAACGACGCACGTAATGCGCCGCAAGCTGG
CCATGCCGTGGCACGCGATCGAAACGGTGCAGGAGGCCGTGCGTGCGCAATGCCGGGTCGAGCCGCTGACGCTCGAAACC
CATGATCTCGGACGGCGTATCGCAGAACGCTACGGATTGTCGGTCTATGACGCACTGATCGTCGCGGCGGCATTGCTTGC
CGGCTGCAACGTTCTGTATTCCGAGGATATGCAGCACGGCCTGGTGATCGAGCAGCATCTGCGCATCGTCAATCCTTTTC
CGGCACGGGCATGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9309.62 Da
• Isoelectric Point: 7.9834

>AT181659 WP_274453100.1 NZ_CP064746:c4729771-4729517 [Aeromonas bestiarum]
MKVTSAKQLSACIKDARLSQKLSQGKVAEKVGIRQDTVSSFELNPESTKLETLFKILAALELSVDIKPRNESSDSPASSW
KEEW

Nucleotide

• Length: 255 bp

>AT181659 NZ_CP086018:532997-533230 [Ralstonia sp. RS642]
ATGCAAGTCTCGAAATGGGGCAACAGCCTCGCTATCCGGCTGCCGGCGGCCGTTGTGGAGGCGCTTCAGCTGCACGAAGG
CGACGACGTCGAGGTGGTGATCGCGGGCGAGCGCTCGTTTGGCGTCCGCCGCAAGCGCGCTGCGCGCGAGCTTTTCGACC
GGATCCACCAATATCGCGGCAAGCTGCCCGCCGATTTCATCTTCGAGCGCGACCAGGCCAATGCCCGCGACTGA