Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 4024503..4025140 Replicon chromosome
Accession NZ_CP064707
Organism Bradyrhizobium sp. 131

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag IVA73_RS18530 Protein ID WP_247370343.1
Coordinates 4024503..4024898 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag IVA73_RS18535 Protein ID WP_085353162.1
Coordinates 4024898..4025140 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IVA73_RS18510 (IVA73_18280) 4020311..4021402 + 1092 WP_247370419.1 patatin-like phospholipase family protein -
IVA73_RS18515 (IVA73_18285) 4021536..4022282 + 747 WP_018457980.1 TetR/AcrR family transcriptional regulator -
IVA73_RS18520 (IVA73_18290) 4022530..4023132 + 603 WP_247903399.1 PepSY domain-containing protein -
IVA73_RS18525 (IVA73_18295) 4023352..4024389 + 1038 WP_247370346.1 aspartate-semialdehyde dehydrogenase -
IVA73_RS18530 (IVA73_18300) 4024503..4024898 - 396 WP_247370343.1 type II toxin-antitoxin system VapC family toxin Toxin
IVA73_RS18535 (IVA73_18305) 4024898..4025140 - 243 WP_085353162.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
IVA73_RS18540 (IVA73_18310) 4025198..4026271 - 1074 WP_247370340.1 tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA -
IVA73_RS18545 (IVA73_18315) 4026414..4026878 - 465 WP_247370337.1 peptidylprolyl isomerase -
IVA73_RS18550 (IVA73_18320) 4026875..4027300 - 426 WP_247370334.1 hypothetical protein -
IVA73_RS18555 (IVA73_18325) 4027309..4027872 - 564 WP_018457989.1 peptidylprolyl isomerase -
IVA73_RS18560 (IVA73_18330) 4027914..4028408 - 495 WP_247370332.1 pantetheine-phosphate adenylyltransferase -
IVA73_RS18565 (IVA73_18335) 4028656..4028913 + 258 WP_018457991.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-87)

Antitoxin

Antitoxin VapB-like

(2-79)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 13999.34 Da        Isoelectric Point: 10.3997

>T181658 WP_247370343.1 NZ_CP064707:c4024898-4024503 [Bradyrhizobium sp. 131]
MVLDTSAIVATVTNEPDGQRYRKAMLDAASLSMSAVAILETKIVLSARFGASAVKFFDELLEIAGIVVVPFDADMAKGAF
EAFQRFGKGRGTSGAAQHRRLCGLRLAKARSQPLLFKGAHFAKTDILPALT

Download         Length: 396 bp

>T181658 NZ_CP086016:c5058763-5058176 [Pseudomonas aeruginosa]
ATGTCGAGGAGGGCGCCCATGTTCAAGCCGCTACCGATCACCCTGCAGCGCGGAGCCTTGCGTCTCGAGCCGCTGGTGGA
AGCGGACATTCCCGAGCTGGTGAGCCTCGCCGAAGCCAACCGCGAGGCGCTGCAGTACATGGACGGACCGACGCGGCCGG
ACTGGTACCGCCAGAGCCTCGCCGAGCAGCGCGAGGGCAGGGCGTTGCCGCTCGCCGTCCGCCTCGGCGTGCAACTGGTC
GGGACCACGCGCTTCGCCGAATTCCTTCCCGCATTGCCGGCCTGCGAGATCGGCTGGACCTGGCTCGACCAGGCCCAGCA
CGGCAGCGGCCTGAACCGCATGATCAAGTACCTGATGCTCAAGCATGCCTTCGACAACCTGCGCATGGTCCGCGTGCAGC
TCAGCACGGCGGCGAGCAACCTGCGCGCCCAGGGCGCCATCGACAAGCTCGGCGCGCAGCGCGAGGGCGTGCTGCGCAAC
CACCGGCGGCTGGCCGGCGGGCGGCTAGACGACACCTTCGTCTACAGCATCACCGACCACGAATGGCCGCAGGTCAAGGC
GGCGCTGGAAGCCAGCTTCACCGGCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8872.03 Da        Isoelectric Point: 4.8146

>AT181658 WP_085353162.1 NZ_CP064707:c4025140-4024898 [Bradyrhizobium sp. 131]
MNIRSAKVDELAQRLARLTGEDIETALERAIEERLSRVASPAVDRRAALTSFFERTAGLPVLDSRPADEILGYDRFGLPS

Download         Length: 243 bp

>AT181658 NZ_CP086016:c5058109-5057255 [Pseudomonas aeruginosa]
GTGCCGGACGAGACGAGCGGAGAACACACGCATTTCTGGCGCGCAGCCGAACTGGGCGGCGTCGAACTGCTGCACGCGCG
CTATGTGGAGCAGCGCTTCGCGCCGCATGTGCACAGCAGCTTCGCCCTGGTCATCATCGAGCAGGGCGCGCAGCGCTTCC
GCCATCGTGGCGGCGAGCACCTGGCCCCGCTGGGCAGCATGGTGCTGATCAACCCCGACGAAGTGCACACCGGCTCCAAG
GCCCATGATGCCGGTTGGCTCTATCGCGGCTACTACCCGGAAATGGAGCAGATCGACGGGATTCTCGACGAGCTGGAAAT
CCATCATGGCGGCGTGCCGCGTTTCGCCGACAGCGTGATCCATGACCAGCCCCTGGCACGCGCCTTCGTCCACTTGCACC
GCCTGCTGGCCGAGCATGCCGGCAGCCTGGAAACCCAGGCCCGCTGGCGCGAGACGATGCTCGCCCTGTTCCGTCGCCAC
GCCCGCCTGCCAGAAGCGCCGAAGGCCGGGCAGGAGCCGTTGGCGGTGGCTCGCGCCCGCGAACTGCTGGCGGCGCGGTT
GCTCGATCCGCCTTCACTGGAGGAACTGGCGGCGGCGGTCAATCTATCCCCGTTCCATTTTGCCCGGGTCTTCCGTCGCG
CCACCGGCATGCCGCCCCACGCCTGGCTCAGGCAGCGCCGGCTGGAGCAGGCCAGGGCACTGCTCAAGAGCGGCCGGGCG
CCGTTGGAGGTGGCTCTGGAGCTGGGCTTCGCCGACCAGAGCCACCTCGGTCGCCAGTTCAAGCAGACCTACGGCGTGGC
ACCGGGTGAATACCGCTCGGCCTGCGCGCGCTCGTCCTTGACGACATACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References