Detailed information of TA system TA181655

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-Phd
• Location: 5900137..5900837
• Replicon: chromosome
• Accession: NZ_CP064704
• Organism: Bradyrhizobium sp. 155

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A1X3E9Q3
• Locus tag: IVA93_RS28540
• Protein ID: WP_018454985.1
• Coordinates: 5900412..5900837 (+)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: IVA93_RS28535
• Protein ID: WP_018454984.1
• Coordinates: 5900137..5900415 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IVA93_RS28515 (IVA93_28245)	5895219..5896121	-	903	WP_018454980.1	sugar ABC transporter permease	-
IVA93_RS28520 (IVA93_28250)	5896121..5897206	-	1086	WP_018454981.1	ABC transporter ATP-binding protein	-
IVA93_RS28525 (IVA93_28255)	5897219..5898358	-	1140	WP_018454982.1	ABC transporter ATP-binding protein	-
IVA93_RS28530 (IVA93_28260)	5898355..5899905	-	1551	WP_085361305.1	glycerol-3-phosphate dehydrogenase	-
IVA93_RS28535 (IVA93_28265)	5900137..5900415	+	279	WP_018454984.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
IVA93_RS28540 (IVA93_28270)	5900412..5900837	+	426	WP_018454985.1	type II toxin-antitoxin system VapC family toxin	Toxin
IVA93_RS28545 (IVA93_28275)	5900840..5901682	-	843	WP_018454986.1	DeoR/GlpR family DNA-binding transcription regulator	-
IVA93_RS28550 (IVA93_28280)	5901774..5902448	-	675	WP_018454987.1	HAD-IA family hydrolase	-
IVA93_RS28555 (IVA93_28285)	5902603..5903079	+	477	WP_026232853.1	nuclear transport factor 2 family protein	-
IVA93_RS28560 (IVA93_28290)	5903310..5903501	-	192	WP_018454989.1	hypothetical protein	-
IVA93_RS28565 (IVA93_28295)	5903724..5904134	-	411	WP_018454990.1	acyl-CoA thioesterase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-123)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (13-74)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 15519.85 Da
• Isoelectric Point: 5.8803

>T181655 WP_018454985.1 NZ_CP064704:5900412-5900837 [Bradyrhizobium sp. 155]
VNLLLDTNVLSEVQRPAPSPKVLSWLDTIDEDRAFISAASIAELRRGIALLEDGRRRAALAAWLARDLPERFAGRTLPID
HAVAERWGDLMAQSRRSGLALSVMDGFFAATALANNLMLVTRNVKDFAVFGVPLLNPWDNP

Nucleotide

• Length: 426 bp

>T181655 NZ_CP086016:1778214-1778561 [Pseudomonas aeruginosa]
ATGTCCCCGGTCGTCATTCGTTTTACTGATACCGCAGAGCAAAGCATCGAAGACCAAGTCCACCACTTGGCTCCATTCCA
AGGTGAACTGGCTGCACTCCAGTCAGTACTGAGCCTTTTGGATGAGATTGAAGAGAAGATTTCACTTGCACCTAAAGGTT
ACCCAGTCAGCCATCAGGCGAGTCTTCTGGGGGTGCTGAGCTATCGCGAGCTTAATACCGGCCCCTATCGTGTTTTTTAC
GAATTCCACGAAGAGCAAGGCGAGGTGGCAGTGATCTTGGTTTTGCGACAGAAGCAGAGCGTTGAGCAGCAATTGATCCG
CTACTGCTTGGTGGGGCCAATCGAGTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10060.30 Da
• Isoelectric Point: 6.0741

>AT181655 WP_018454984.1 NZ_CP064704:5900137-5900415 [Bradyrhizobium sp. 155]
MTEHTAPDSPATDSWTLANAKARLSEVIDRAQAGPQIITRHGKPNAVIVSVEEWARKTARKGTLAEFLLASPLRSGDLEL
ERVHDAPHDELP

Nucleotide

• Length: 279 bp

>AT181655 NZ_CP086016:1777953-1778204 [Pseudomonas aeruginosa]
ATGCGAGTCGAGACAATTAGTTATTTGAAACGTCATGCGGCTGACCTGGATTTATCCGAGCCAATGGTCGTCACGCAGAA
CGGTGTTCCTGCCTATGTGGTTGAGTCATATGCTGAGCGGAAGCAGCGCGATGAAGCAATTGCGCTGGTGAAGTTGCTTG
CGATTGGCTCCCGCCAGTACGCAGAAGGCAAGCATCGCTCTGTTGATGATTTGAAAGCTCGCCTTTCCAGGAGGTTCGCT
CAGCCAGAATAA

Structures

Toxin

• AlphaFold DB: A0A1X3E9Q3