Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 3756872..3757509 Replicon chromosome
Accession NZ_CP064704
Organism Bradyrhizobium sp. 155

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag IVA93_RS18310 Protein ID WP_247789896.1
Coordinates 3757114..3757509 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag IVA93_RS18305 Protein ID WP_085353162.1
Coordinates 3756872..3757114 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IVA93_RS18275 (IVA93_18120) 3753099..3753356 - 258 WP_018457991.1 hypothetical protein -
IVA93_RS18280 (IVA93_18125) 3753604..3754098 + 495 WP_247370332.1 pantetheine-phosphate adenylyltransferase -
IVA93_RS18285 (IVA93_18130) 3754140..3754703 + 564 WP_018457989.1 peptidylprolyl isomerase -
IVA93_RS18290 (IVA93_18135) 3754712..3755137 + 426 WP_247370334.1 hypothetical protein -
IVA93_RS18295 (IVA93_18140) 3755134..3755598 + 465 WP_247370337.1 peptidylprolyl isomerase -
IVA93_RS18300 (IVA93_18145) 3755741..3756814 + 1074 WP_247370340.1 tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA -
IVA93_RS18305 (IVA93_18150) 3756872..3757114 + 243 WP_085353162.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
IVA93_RS18310 (IVA93_18155) 3757114..3757509 + 396 WP_247789896.1 type II toxin-antitoxin system VapC family toxin Toxin
IVA93_RS18315 (IVA93_18160) 3757623..3758660 - 1038 WP_247789897.1 aspartate-semialdehyde dehydrogenase -
IVA93_RS18320 (IVA93_18165) 3758880..3759482 - 603 WP_247370350.1 PepSY domain-containing protein -
IVA93_RS18325 (IVA93_18170) 3759730..3760476 - 747 WP_018457980.1 TetR/AcrR family transcriptional regulator -
IVA93_RS18330 (IVA93_18175) 3760610..3761701 - 1092 WP_247370419.1 patatin-like phospholipase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-87)

Antitoxin

Antitoxin VapB-like

(2-79)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 13900.20 Da        Isoelectric Point: 10.1491

>T181654 WP_247789896.1 NZ_CP064704:3757114-3757509 [Bradyrhizobium sp. 155]
MVLDTSAIVATVTNEPDGQRYRKAMLDAASLSMSAVAILETKIVLSARFGASAVKFFDELLEIAGIVVVPFDADMAKGAF
EAFQRFGKGRGTSGAAQHRRLCGLGLAKARSQPLLFKGAHFAKTDILPALT

Download         Length: 396 bp

>T181654 NZ_CP086016:1430583-1430765 [Pseudomonas aeruginosa]
ATGCGGAGTAGGGAAGTGATTGATTTGCTGTTGGAGGATGGCTGGTATGAAGTGGCGGTGAAAGGTAGCCACCACCAGTT
CAAACATCCTTCAAAGCCTGGAAAGGTGACGGTTCAACATCCGTCCTCGACGATACCGAAAGGAACCCTGAACAACATAC
TGAAACAAGCCGGCCTCAAGTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8872.03 Da        Isoelectric Point: 4.8146

>AT181654 WP_085353162.1 NZ_CP064704:3756872-3757114 [Bradyrhizobium sp. 155]
MNIRSAKVDELAQRLARLTGEDIETALERAIEERLSRVASPAVDRRAALTSFFERTAGLPVLDSRPADEILGYDRFGLPS

Download         Length: 243 bp

>AT181654 NZ_CP086016:1430793-1431197 [Pseudomonas aeruginosa]
ATGAAATTCCCCGTGGTGTTACACAAAGACCCTGATTCTGACTATGGCGTGACTGTGCCCGATGTGCCGGGTTGCTTCTC
TGCCGGCGCTACGGTGTCCGAGGCCCTGGCCAATGTAGAAGAGGCGCTGGCCTTGCACTTCGAAGGCTTGGTTACGGACG
GCGAAGAGCTACCCCAGCCGCAGGACGTTGACGCCCATATGAAGAATCCGGACTTCGAAGGTGGCGTATGGGCGGTGGTT
GACTTCGACGTGACCCCGTACCTGGGCAAGGCCGTACGCTTTAATGCGACGCTCCCGGAACACCTTCTGCAGCGGATCGA
TGAGCGCGTGAAGGTGGATAAGCGCTATCAGTCTCGGTCGGGCTTTCTGGCAACAGCGGCGATGCGCGAACTGTCAGTGG
CGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References