Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 283634..284265 Replicon chromosome
Accession NZ_CP064703
Organism Bradyrhizobium sp. 170

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag IVB05_RS01370 Protein ID WP_247782671.1
Coordinates 283861..284265 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag IVB05_RS01365 Protein ID WP_247782670.1
Coordinates 283634..283864 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IVB05_RS01345 (IVB05_01335) 278772..280502 - 1731 WP_247782667.1 hypothetical protein -
IVB05_RS01350 (IVB05_01340) 280879..281718 + 840 WP_247782668.1 caspase family protein -
IVB05_RS01355 (IVB05_01345) 282126..282407 - 282 WP_247787425.1 GIY-YIG nuclease family protein -
IVB05_RS01360 (IVB05_01350) 282546..283439 - 894 WP_247782669.1 efflux RND transporter periplasmic adaptor subunit -
IVB05_RS01365 (IVB05_01355) 283634..283864 + 231 WP_247782670.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
IVB05_RS01370 (IVB05_01360) 283861..284265 + 405 WP_247782671.1 PIN domain-containing protein Toxin
IVB05_RS01375 (IVB05_01365) 284318..284722 - 405 WP_247782672.1 alpha/beta hydrolase -
IVB05_RS01380 (IVB05_01370) 284769..285614 - 846 WP_247782673.1 class I SAM-dependent methyltransferase -
IVB05_RS01385 (IVB05_01375) 285973..287553 + 1581 WP_247782674.1 winged helix-turn-helix domain-containing protein -
IVB05_RS01390 (IVB05_01380) 287677..287904 + 228 WP_247782675.1 tautomerase family protein -
IVB05_RS01395 (IVB05_01385) 288119..288385 + 267 WP_247782676.1 DUF1127 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-113)

Antitoxin

SpoVT-AbrB domain

(5-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14555.67 Da        Isoelectric Point: 6.3215

>T181651 WP_247782671.1 NZ_CP064703:283861-284265 [Bradyrhizobium sp. 170]
VKAFFDTNILVYTATSDARKQRAVDCLSRGGVVSVQVLNEFVHVARRKLRHDWPQIELALGLFRASLDDVLPVTLNIHTG
AVSLAREHGVPFYDALIVAAAIEAGCDTLFSEDMQHGRSIGGLAIVNPFLDSAP

Download         Length: 405 bp

>T181651 NZ_CP086016:c144775-144494 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8707.97 Da        Isoelectric Point: 5.1599

>AT181651 WP_247782670.1 NZ_CP064703:283634-283864 [Bradyrhizobium sp. 170]
MQVSKWGDSLAVRLPKALVEKMGLRAGDELDIVDVAERTLIVQKEDRRKAALERLASLNWALPPDYKFDRDEANER

Download         Length: 231 bp

>AT181651 NZ_CP086016:c144999-144772 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References