Detailed information of TA system TA181645

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-Phd
• Location: 1850281..1850981
• Replicon: chromosome
• Accession: NZ_CP064693
• Organism: Bradyrhizobium sp. 187

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A1X3E9Q3
• Locus tag: IVB19_RS08855
• Protein ID: WP_018454985.1
• Coordinates: 1850281..1850706 (-)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: IVB19_RS08860
• Protein ID: WP_018454984.1
• Coordinates: 1850703..1850981 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IVB19_RS08830 (IVB19_08725)	1846984..1847394	+	411	WP_018454990.1	acyl-CoA thioesterase	-
IVB19_RS08835 (IVB19_08730)	1847617..1847808	+	192	WP_018454989.1	hypothetical protein	-
IVB19_RS08840 (IVB19_08735)	1848039..1848515	-	477	WP_026232853.1	nuclear transport factor 2 family protein	-
IVB19_RS08845 (IVB19_08740)	1848670..1849344	+	675	WP_018454987.1	HAD-IA family hydrolase	-
IVB19_RS08850 (IVB19_08745)	1849436..1850278	+	843	WP_018454986.1	DeoR/GlpR family DNA-binding transcription regulator	-
IVB19_RS08855 (IVB19_08750)	1850281..1850706	-	426	WP_018454985.1	type II toxin-antitoxin system VapC family toxin	Toxin
IVB19_RS08860 (IVB19_08755)	1850703..1850981	-	279	WP_018454984.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
IVB19_RS08865 (IVB19_08760)	1851212..1852762	+	1551	WP_085361305.1	glycerol-3-phosphate dehydrogenase	-
IVB19_RS08870 (IVB19_08765)	1852759..1853898	+	1140	WP_018454982.1	ABC transporter ATP-binding protein	-
IVB19_RS08875 (IVB19_08770)	1853911..1854996	+	1086	WP_247821329.1	ABC transporter ATP-binding protein	-
IVB19_RS08880 (IVB19_08775)	1854996..1855898	+	903	WP_018454980.1	sugar ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-123)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (13-74)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 15519.85 Da
• Isoelectric Point: 5.8803

>T181645 WP_018454985.1 NZ_CP064693:c1850706-1850281 [Bradyrhizobium sp. 187]
VNLLLDTNVLSEVQRPAPSPKVLSWLDTIDEDRAFISAASIAELRRGIALLEDGRRRAALAAWLARDLPERFAGRTLPID
HAVAERWGDLMAQSRRSGLALSVMDGFFAATALANNLMLVTRNVKDFAVFGVPLLNPWDNP

Nucleotide

• Length: 426 bp

>T181645 NZ_CP086010:c2472218-2472039 [Pseudomonas aeruginosa]
ATGAAGTTCAGCGAATTCAGACGATGGTTGAAGGCCCAAGGGGTGACCTTCGAAGCCGGCAAGGGAAGCCACTTCAAGAT
CACCGCCCCGAACGGCAAAACGACCACCTTCGCGAACCACGGAGCTAAGGAAATGCCCGAACCGACCCGCAAGGCGATCA
TCAAGCAACTGGGGCTCTAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10060.30 Da
• Isoelectric Point: 6.0741

>AT181645 WP_018454984.1 NZ_CP064693:c1850981-1850703 [Bradyrhizobium sp. 187]
MTEHTAPDSPATDSWTLANAKARLSEVIDRAQAGPQIITRHGKPNAVIVSVEEWARKTARKGTLAEFLLASPLRSGDLEL
ERVHDAPHDELP

Nucleotide

• Length: 279 bp

>AT181645 NZ_CP086010:c2471993-2471271 [Pseudomonas aeruginosa]
ATGTACGACTATGCAATTCGATTCGAACAGGACGACAGCGCGCCTGGCGTTGCCGTTTTTTGCCGAGACTTGCCGGAGCT
GAACAGCTTCGGCGATGACCGCGAGCATGCGATCCAGGAGGCGATGGACGCCATCGAGACGACCCTGTCGCTGTACGTTG
ATGCGCGCAAGCCGATCCCGGAAGCAACTCCGCCAGAGGAAGGCGAGCACGTCGTCCATCTTCCGGCCGTCACCGTGGCG
AAGATCGCGCTGTGGAACGAGATGATGAAGCGCGGAATGCGCAAGTCCGACCTGTGCAAGCTTCTGGGTATCGCACAGAC
CCAGGGCGATCGGCTCGTCGACTTCCTACACAACACGAAGATGGATGCTGTAGAGGCGGCATTGCTGGCTTTGGGCACCC
GCCTTCGACAGTCAGTGGAAGTCAGGTTCGACTGGGTGAAGCTGCGGCATGAGCGCGCCGACGATGTCATTCTCGTGGAG
GTCTGGTGTGAAATGGTCTCTTCCGGTCACGACGAAACCGGAAATGAGCAGGGCTGGGTGAGCTTGCCTAGCCAACTGTC
CACCACTTGGAACCAAATCAAGGCAATGGAGGCCCACCAGTTCGCAACTGGTCGCCAATTCAGCATATCGGTGGACGATG
ACAGGCCTGGCGAATCTCGGTTCGAATCGCTGGGTCGCATTCACCTGCCCGTGACGTTCTACGCTGCAAGAGTCAGTGCC
TGA

Structures

Toxin

• AlphaFold DB: A0A1X3E9Q3