Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 4303664..4304322 Replicon chromosome
Accession NZ_CP064692
Organism Bradyrhizobium sp. 191

Toxin (Protein)


Gene name vapC Uniprot ID A0A151FQ34
Locus tag IVB23_RS19980 Protein ID WP_061880190.1
Coordinates 4303918..4304322 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A151FPY6
Locus tag IVB23_RS19975 Protein ID WP_061880191.1
Coordinates 4303664..4303918 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IVB23_RS19955 (IVB23_19800) 4299106..4299585 - 480 WP_247799767.1 DUF1579 domain-containing protein -
IVB23_RS19960 (IVB23_19805) 4299590..4300786 - 1197 WP_247799768.1 ADP-forming succinate--CoA ligase subunit beta -
IVB23_RS19965 (IVB23_19810) 4301006..4301974 - 969 WP_028177733.1 malate dehydrogenase -
IVB23_RS19970 (IVB23_19815) 4302302..4303489 - 1188 WP_247799769.1 cell division protein ZapE -
IVB23_RS19975 (IVB23_19820) 4303664..4303918 + 255 WP_061880191.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
IVB23_RS19980 (IVB23_19825) 4303918..4304322 + 405 WP_061880190.1 type II toxin-antitoxin system VapC family toxin Toxin
IVB23_RS19985 (IVB23_19830) 4304339..4304875 - 537 WP_061880189.1 RNA 2',3'-cyclic phosphodiesterase -
IVB23_RS19990 (IVB23_19835) 4305050..4305685 - 636 WP_247804938.1 arylesterase -
IVB23_RS19995 (IVB23_19840) 4305741..4306463 + 723 WP_194390809.1 ABC transporter ATP-binding protein -
IVB23_RS20000 (IVB23_19845) 4306460..4309030 + 2571 WP_247799770.1 FtsX-like permease family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14436.58 Da        Isoelectric Point: 5.2438

>T181644 WP_061880190.1 NZ_CP064692:4303918-4304322 [Bradyrhizobium sp. 191]
MVIDTSAIVAIALNEADAGDIERLIVDDPIRLISAATVIEATMVIETRLGEAGGREFDLWLVKMGAEIVAVDAAQADAAR
RAWRRYGKGRHAASLNYGDCFSYALAMTRGEPLLFKGEDFAKTGIRRAGAALPR

Download         Length: 405 bp

>T181644 NZ_CP086010:1932198-1932785 [Pseudomonas aeruginosa]
ATGTCGAGGAGGGCGCCCATGTTCAAGCCGCTACCGATCACCCTGCAGCGCGGAGCCTTGCGTCTCGAGCCGCTGGTGGA
AGCGGACATTCCCGAGCTGGTGAGCCTCGCCGAAGCCAACCGCGAGGCGCTGCAGTACATGGACGGACCGACGCGGCCGG
ACTGGTACCGCCAGAGCCTCGCCGAGCAGCGCGAGGGCAGGGCGTTGCCGCTCGCCGTCCGCCTCGGCGTGCAACTGGTC
GGGACCACGCGCTTCGCCGAGTTCCTTCCCGCCTTGCCGGCCTGCGAGATCGGCTGGACCTGGCTCGACCAGGCCCAGCA
CGGCAGCGGCCTGAACCGCATGATCAAGTACCTGATGCTCAAGCATGCCTTCGACAACCTGCGCATGGTCCGCGTGCAGC
TCAGCACGGCGGCGAGCAACCTGCGCGCCCAGGGCGCCATCGACAAGCTCGGCGCGCAGCGCGAGGGCGTGCTGCGCAAC
CACCGGCGGCTGGCCGGCGGGCGGCTAGACGACACCTTCGTCTACAGCATCACCGACCACGAATGGCCGCAGGTCAAGGC
GGCGCTGGAAGCCAGCTTCACCGGCTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9716.93 Da        Isoelectric Point: 4.9167

>AT181644 WP_061880191.1 NZ_CP064692:4303664-4303918 [Bradyrhizobium sp. 191]
MALSIKDPETEQLARSLAQLTGENITTATRRAIEERLRRLNAQTSKDALLEDLAEIRRRWSEMRVVDDRTPEEILGYDEH
GLPR

Download         Length: 255 bp

>AT181644 NZ_CP086010:1932852-1933706 [Pseudomonas aeruginosa]
GTGCCGGACGAGACGAGCGGAGAACACACGCATTTCTGGCGCGCCGCCGAACTGGGCGGCGTCGAACTGCTGCACGCGCG
CTATGTGGAGCAGCGCTTCGCGCCGCACGTGCACAGCAGCTTCGCCCTAGTCATCATCGAGCAGGGCGCGCAGCGCTTCC
GCCATCGTGGCGGCGAGCACCTAGCCCCGCTGGGCAGCATGGTGCTGATCAACCCCGACGAAGTGCACACCGGCTCCAAG
GCCCATGATGCCGGTTGGCTCTATCGCGGCTACTACCCGGAAATGGAACAGATCGACGGGATTCTCGACGAGCTGGAAAT
CCATCATGGCGGCGTGCCGCGTTTCGCCGACAGCGTGATCCACGACCAGCCCCTGGCACGCGCCTTCGTCCACTTGCACC
GCCTGCTGGCCGAGCATGCCGGCAGCCTGGAAACCCAGACCCGCTGGCGCGAGACGATGCTCGCCCTGTTCCGTCGCCAC
GCCCGCCTGCCAGAAGCGCCGAAGGCCGGGCAGGAGCCGTTGGCGGTGGCCCGCGCCCGCGAACTGCTGGCGGCGCGGTT
GCTCGATCCGCCTTCTCTGGAGGAACTGGCGGCGGCGGTCAATCTGTCCCCGTTCCATTTTGCCCGGGTCTTCCGTCGCG
CCACCGGCATGCCGCCCCACGCCTGGCTCAGACAGCGCCGCCTGGAGCAGGCCAGGGCACTGCTCAAGAGCGGCCGGGCG
CCGCTGGAGGTGGCCCTGGAGCTGGGCTTCGCCGACCAGAGCCACCTCGGTCGCCAGTTCAAGCAGGCCTACGGGGTGGC
ACCGGGTGAATACCGCTCGGCCTGCGCGCGCTCGTCCTTGACGACATACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A151FQ34

Antitoxin

Source ID Structure
AlphaFold DB A0A151FPY6

References