Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 1443897..1444489 Replicon chromosome
Accession NZ_CP064690
Organism Bradyrhizobium sp. 192

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag IVB24_RS06805 Protein ID WP_094976673.1
Coordinates 1444301..1444489 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag IVB24_RS06800 Protein ID WP_094976672.1
Coordinates 1443897..1444295 (-) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IVB24_RS06780 (IVB24_06780) 1439858..1440277 - 420 WP_094976668.1 thioesterase family protein -
IVB24_RS06785 (IVB24_06785) 1440290..1441051 - 762 WP_247772505.1 SDR family NAD(P)-dependent oxidoreductase -
IVB24_RS06790 (IVB24_06790) 1441079..1442962 - 1884 WP_247772506.1 feruloyl-CoA synthase -
IVB24_RS06795 (IVB24_06795) 1442959..1443768 - 810 WP_094976671.1 crotonase/enoyl-CoA hydratase family protein -
IVB24_RS06800 (IVB24_06800) 1443897..1444295 - 399 WP_094976672.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
IVB24_RS06805 (IVB24_06805) 1444301..1444489 - 189 WP_094976673.1 type II toxin-antitoxin system HicA family toxin Toxin
IVB24_RS06810 (IVB24_06810) 1444534..1444995 - 462 WP_247772507.1 DUF3237 domain-containing protein -
IVB24_RS06815 (IVB24_06815) 1445008..1446327 - 1320 WP_094976675.1 TRAP transporter permease -
IVB24_RS06820 (IVB24_06820) 1446330..1446839 - 510 WP_094976676.1 TRAP transporter small permease -
IVB24_RS06825 (IVB24_06825) 1447043..1448059 - 1017 WP_094976677.1 TRAP transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-124)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7009.08 Da        Isoelectric Point: 11.9537

>T181636 WP_094976673.1 NZ_CP064690:c1444489-1444301 [Bradyrhizobium sp. 192]
MNSRDIISALHRDGWVQVAQKGSHVQFRHPTKKGRVTVPHPKRDIALGTLKSIEQQSGLQLR

Download         Length: 189 bp

>T181636 NZ_CP085987:3659127-3659402 [Salmonella enterica]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14103.83 Da        Isoelectric Point: 4.2376

>AT181636 WP_094976672.1 NZ_CP064690:c1444295-1443897 [Bradyrhizobium sp. 192]
MRHYIGLIHKDADSDFGVSFPDLPGVVTAGSTLDEARDMAEEALAFHLEGLEEDGEAIPEPSSLEDIMSDPANRSGVAIL
VSVKDGQPKIVRVNVTLPGDVLEQIDKYAEAHGYTRSGLLAQAAKKLMTEAA

Download         Length: 399 bp

>AT181636 NZ_CP085987:3658864-3659124 [Salmonella enterica]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCCCGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References