Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 8381451..8382082 Replicon chromosome
Accession NZ_CP064689
Organism Bradyrhizobium sp. 200

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag IVB30_RS39615 Protein ID WP_247832538.1
Coordinates 8381451..8381849 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag IVB30_RS39620 Protein ID WP_247832539.1
Coordinates 8381849..8382082 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IVB30_RS39600 (IVB30_39210) 8377037..8377228 - 192 WP_247832535.1 DUF1192 domain-containing protein -
IVB30_RS39605 (IVB30_39215) 8377332..8378330 + 999 WP_247832536.1 NAD(P)H-quinone oxidoreductase -
IVB30_RS39610 (IVB30_39220) 8378452..8381328 + 2877 WP_247832537.1 EAL domain-containing protein -
IVB30_RS39615 (IVB30_39225) 8381451..8381849 - 399 WP_247832538.1 tRNA(fMet)-specific endonuclease VapC Toxin
IVB30_RS39620 (IVB30_39230) 8381849..8382082 - 234 WP_247832539.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
IVB30_RS39625 (IVB30_39235) 8382279..8383826 - 1548 WP_247832540.1 L,D-transpeptidase -
IVB30_RS39630 (IVB30_39240) 8384126..8384662 - 537 WP_247832541.1 GNAT family N-acetyltransferase -
IVB30_RS39635 (IVB30_39245) 8385034..8385684 - 651 WP_247832542.1 hypothetical protein -
IVB30_RS39640 (IVB30_39250) 8385681..8386181 - 501 WP_247838474.1 c-type cytochrome -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-56)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14796.02 Da        Isoelectric Point: 7.0498

>T181635 WP_247832538.1 NZ_CP064689:c8381849-8381451 [Bradyrhizobium sp. 200]
MLTYMLDTNICIYVMKNYPIELREKFNALAEQLCISSITLGELHYGAEKSARRAHNLTAIEHFVARLDVLPFAEKAAAHY
GQVRAELERAGTPGGPHDMQIGGHARSEGLIVVTNNMREFARMPGVRAENWI

Download         Length: 399 bp

>T181635 NZ_CP085987:3610791-3611159 [Salmonella enterica]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAAGCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGCCGTTCGCTTACGTGCCTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8772.97 Da        Isoelectric Point: 10.2948

>AT181635 WP_247832539.1 NZ_CP064689:c8382082-8381849 [Bradyrhizobium sp. 200]
MTSSTVFTSNRSQAVRLPKAVAFPENVHHVDILKIGRSRVIVPQGKRWDDLFQNGPRASEDFMVERKQPAAEEREPL

Download         Length: 234 bp

>AT181635 NZ_CP085987:3610573-3610794 [Salmonella enterica]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGTGCGGTGACGGGGGGGCCTGTTAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References