Detailed information of TA system TA181628

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-Phd
• Location: 1871592..1872295
• Replicon: chromosome
• Accession: NZ_CP064686
• Organism: Bradyrhizobium sp. 4

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: IVB45_RS08545
• Protein ID: WP_247357058.1
• Coordinates: 1871592..1872017 (-)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: IVB45_RS08550
• Protein ID: WP_247357256.1
• Coordinates: 1872014..1872295 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IVB45_RS08515 (IVB45_08370)	1867547..1867957	+	411	WP_247357062.1	acyl-CoA thioesterase	-
IVB45_RS08520 (IVB45_08375)	1868174..1868365	+	192	WP_007595173.1	hypothetical protein	-
IVB45_RS08525 (IVB45_08380)	1868591..1868986	-	396	WP_027568530.1	nuclear transport factor 2 family protein	-
IVB45_RS08530 (IVB45_08385)	1869350..1869826	-	477	WP_247357061.1	nuclear transport factor 2 family protein	-
IVB45_RS08535 (IVB45_08390)	1869981..1870655	+	675	WP_247357060.1	HAD-IA family hydrolase	-
IVB45_RS08540 (IVB45_08395)	1870747..1871589	+	843	WP_247357059.1	DeoR/GlpR family DNA-binding transcription regulator	-
IVB45_RS08545 (IVB45_08400)	1871592..1872017	-	426	WP_247357058.1	type II toxin-antitoxin system VapC family toxin	Toxin
IVB45_RS08550 (IVB45_08405)	1872014..1872295	-	282	WP_247357256.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
IVB45_RS08555 (IVB45_08410)	1872527..1874077	+	1551	WP_247357057.1	glycerol-3-phosphate dehydrogenase	-
IVB45_RS08560 (IVB45_08415)	1874074..1875213	+	1140	WP_247357056.1	ABC transporter ATP-binding protein	-
IVB45_RS08565 (IVB45_08420)	1875226..1876311	+	1086	WP_027568538.1	ABC transporter ATP-binding protein	-
IVB45_RS08570 (IVB45_08425)	1876311..1877213	+	903	WP_007595151.1	sugar ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-123)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (14-76)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 15477.72 Da
• Isoelectric Point: 5.1554

>T181628 WP_247357058.1 NZ_CP064686:c1872017-1871592 [Bradyrhizobium sp. 4]
VNLLLDTNVLSEVQRPAPSPKVLSWLDTIDEDRAFISVASIAELRRGIALLEDGRRRAALAAWLAHDLPERFAGRTLSID
HAVAERWGDLMAQSRRSGVALSVMDGFFAATALANNLMLVTRNVTDFAVFGVPLLNPWDNP

Nucleotide

• Length: 426 bp

>T181628 NZ_CP085987:2042701-2042976 [Salmonella enterica]
ATGAATGCCTCCGGCGTCAGCGTCCGCCATATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCACGGCGTCACCGTGAAGATCTCCGAGGGGTGTT
TGATCCTGATTGCAGAGACGGACGAAGTGAGGGATCTACGGAAGGAGCTTTATCAGGTGAAAAAGTCGATGAAGCATATT
AAGGCGGGGGTAAATAATGTGGTGAACGGGGATTAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10110.31 Da
• Isoelectric Point: 5.6158

>AT181628 WP_247357256.1 NZ_CP064686:c1872295-1872014 [Bradyrhizobium sp. 4]
MTDNSTAPESPATDSWTLANAKARLSEVIDRAQAGPQIITRHGKPNAVIVSAEEWARKTARKGTLAEFLLASPLRSADLE
LERVHDAPHDELP

Nucleotide

• Length: 282 bp

>AT181628 NZ_CP085987:c2042966-2042544 [Salmonella enterica]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT