Detailed information of TA system TA181626

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-Phd
• Location: 6089416..6090116
• Replicon: chromosome
• Accession: NZ_CP064684
• Organism: Bradyrhizobium sp. CW1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A1X3E9Q3
• Locus tag: IVB54_RS29655
• Protein ID: WP_018454985.1
• Coordinates: 6089691..6090116 (+)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: IVB54_RS29650
• Protein ID: WP_018454984.1
• Coordinates: 6089416..6089694 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IVB54_RS29630 (IVB54_29300)	6084499..6085401	-	903	WP_018454980.1	sugar ABC transporter permease	-
IVB54_RS29635 (IVB54_29305)	6085401..6086486	-	1086	WP_247776569.1	ABC transporter ATP-binding protein	-
IVB54_RS29640 (IVB54_29310)	6086499..6087638	-	1140	WP_247776570.1	ABC transporter ATP-binding protein	-
IVB54_RS29645 (IVB54_29315)	6087635..6089185	-	1551	WP_085361305.1	glycerol-3-phosphate dehydrogenase	-
IVB54_RS29650 (IVB54_29320)	6089416..6089694	+	279	WP_018454984.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
IVB54_RS29655 (IVB54_29325)	6089691..6090116	+	426	WP_018454985.1	type II toxin-antitoxin system VapC family toxin	Toxin
IVB54_RS29660 (IVB54_29330)	6090119..6090961	-	843	WP_018454986.1	DeoR/GlpR family DNA-binding transcription regulator	-
IVB54_RS29665 (IVB54_29335)	6091053..6091727	-	675	WP_018454987.1	HAD-IA family hydrolase	-
IVB54_RS29670 (IVB54_29340)	6091882..6092358	+	477	WP_026232853.1	nuclear transport factor 2 family protein	-
IVB54_RS29675 (IVB54_29345)	6092589..6092780	-	192	WP_018454989.1	hypothetical protein	-
IVB54_RS29680 (IVB54_29350)	6093003..6093413	-	411	WP_018454990.1	acyl-CoA thioesterase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-123)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (13-74)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 15519.85 Da
• Isoelectric Point: 5.8803

>T181626 WP_018454985.1 NZ_CP064684:6089691-6090116 [Bradyrhizobium sp. CW1]
VNLLLDTNVLSEVQRPAPSPKVLSWLDTIDEDRAFISAASIAELRRGIALLEDGRRRAALAAWLARDLPERFAGRTLPID
HAVAERWGDLMAQSRRSGLALSVMDGFFAATALANNLMLVTRNVKDFAVFGVPLLNPWDNP

Nucleotide

• Length: 426 bp

>T181626 NZ_CP085987:763895-764179 [Salmonella enterica]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGGCTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAATGACACGACACAGAAGCTAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10060.30 Da
• Isoelectric Point: 6.0741

>AT181626 WP_018454984.1 NZ_CP064684:6089416-6089694 [Bradyrhizobium sp. CW1]
MTEHTAPDSPATDSWTLANAKARLSEVIDRAQAGPQIITRHGKPNAVIVSVEEWARKTARKGTLAEFLLASPLRSGDLEL
ERVHDAPHDELP

Nucleotide

• Length: 279 bp

>AT181626 NZ_CP085987:763657-763905 [Salmonella enterica]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGCAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Structures

Toxin

• AlphaFold DB: A0A1X3E9Q3