Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 138795..140418 Replicon plasmid p14076A
Accession NZ_CP064675
Organism Salmonella sp. SJTUF14076

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag HU143_RS23370 Protein ID WP_000088046.1
Coordinates 138795..140120 (-) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag HU143_RS23375 Protein ID WP_024136327.1
Coordinates 140125..140418 (-) Length 98 a.a.

Genomic Context

HU143_RS23335HU143_RS23345HU143_RS23385HU143_RS23390HU143_RS23395HU143_RS23340HU143_RS23350HU143_RS23355HU143_RS23360HU143_RS23365HU143_RS23370HU143_RS23375HU143_RS23380HU143_RS23400
Location: 134134..134784 (651 bp)
Type: Others
Protein ID: WP_001493764.1
Location: 135191..135895 (705 bp)
Type: Others
Protein ID: WP_001067855.1
Location: 141787..142128 (342 bp)
Type: Others
Protein ID: WP_001151575.1
Location: 142220..142411 (192 bp)
Type: Others
Protein ID: WP_000398480.1
Location: 142461..142742 (282 bp)
Type: Others
Protein ID: WP_000077926.1
Location: 134816..135058 (243 bp)
Type: Others
Protein ID: WP_000844627.1
Location: 136509..136934 (426 bp)
Type: Others
Protein ID: WP_001043843.1
Location: 137188..138003 (816 bp)
Type: Others
Protein ID: WP_053276223.1
Location: 138016..138426 (411 bp)
Type: Others
Protein ID: WP_000985911.1
Location: 138528..138734 (207 bp)
Type: Others
Protein ID: WP_000134171.1
Location: 138795..140120 (1326 bp)
Type: Toxin
Protein ID: WP_000088046.1
Location: 140125..140418 (294 bp)
Type: Antitoxin
Protein ID: WP_024136327.1
Location: 141022..141414 (393 bp)
Type: Others
Protein ID: WP_000341066.1
Location: 143305..144546 (1242 bp)
Type: Others
Protein ID: WP_001053338.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HU143_RS23335134134..134784+651WP_001493764.1tetracycline resistance transcriptional repressor TetR(A)-
HU143_RS23340134816..135058-243WP_000844627.1transposase-
HU143_RS23345135191..135895+705WP_001067855.1IS6-like element IS26 family transposase-
HU143_RS23350136509..136934-426WP_001043843.1hypothetical protein-
HU143_RS23355137188..138003-816WP_053276223.1HNH endonuclease-
HU143_RS23360138016..138426-411WP_000985911.1hypothetical protein-
HU143_RS23365138528..138734-207WP_000134171.1hypothetical protein-
HU143_RS23370138795..140120-1326WP_000088046.1type II toxin-antitoxin system HipA family toxinToxin
HU143_RS23375140125..140418-294WP_024136327.1helix-turn-helix transcriptional regulatorAntitoxin
HU143_RS23380141022..141414-393WP_000341066.1hypothetical protein-
HU143_RS23385141787..142128+342WP_001151575.1hypothetical protein-
HU143_RS23390142220..142411+192WP_000398480.1hypothetical protein-
HU143_RS23395142461..142742+282WP_000077926.1hypothetical protein-
HU143_RS23400143305..144546-1242WP_001053338.1VWA domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideConjugative plasmidtet(A)-1..227512227512


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T181410 WP_000088046.1 NZ_CP064675:c140120-138795 [Salmonella sp. SJTUF14076]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

>T181410 NZ_CP085841:2791205-2791348 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTTAAAAAAGACAATAAAAAATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT181410 WP_024136327.1 NZ_CP064675:c140418-140125 [Salmonella sp. SJTUF14076]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp

>AT181410 NZ_CP085841:c2791542-2791280 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGAGGGTCGTTGTGCTATA
ATGGTAATGAAAAGAGAGATATGCTGTAACATACCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTCTTTTTTAACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A3T0VBU1

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A5Z6V2D1

References