181408

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4527761..4528377 Replicon chromosome
Accession NZ_CP064674
Organism Salmonella sp. SJTUF14076

Toxin (Protein)


Gene name vapC Uniprot ID Q8Z2U3
Locus tag HU143_RS21700 Protein ID WP_000238494.1
Coordinates 4527761..4528135 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8E9YHE9
Locus tag HU143_RS21705 Protein ID WP_001523745.1
Coordinates 4528135..4528377 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HU143_RS21685 4525263..4526165 + 903 WP_051129234.1 formate dehydrogenase subunit beta -
HU143_RS21690 4526162..4526797 + 636 WP_000829028.1 formate dehydrogenase cytochrome b556 subunit -
HU143_RS21695 4526794..4527723 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
HU143_RS21700 4527761..4528135 - 375 WP_000238494.1 type II toxin-antitoxin system VapC family toxin Toxin
HU143_RS21705 4528135..4528377 - 243 WP_001523745.1 ribbon-helix-helix domain-containing protein Antitoxin
HU143_RS21710 4528582..4529511 + 930 WP_001162861.1 alpha/beta hydrolase -
HU143_RS21715 4529597..4529908 + 312 WP_000558165.1 type II toxin-antitoxin system HigB family toxin -
HU143_RS21720 4529905..4530351 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin -
HU143_RS21725 4530366..4531307 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
HU143_RS21730 4531352..4531789 - 438 WP_000560969.1 D-tyrosyl-tRNA(Tyr) deacylase -
HU143_RS21735 4531786..4532658 - 873 WP_000921423.1 virulence factor BrkB family protein -
HU143_RS21740 4532652..4533251 - 600 WP_023227076.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13908.18 Da        Isoelectric Point: 7.3567

>T181408 WP_000238494.1 NZ_CP064674:c4528135-4527761 [Salmonella sp. SJTUF14076]
MVKGSALFDTNILIDLFSGRIEAKHALEAYPPQNAISLITWMEVMVGAKKYHQENRTRIALSAFNIIGVTQEIAERSVIV
RQEYGMKLPDAIILATAQVHRCELVTRNTKDFADIPGVITPYHL

Download         Length: 375 bp

>T181408 NZ_CP085841:2790771-2790911 [Enterococcus faecalis]
ATTTCTCTGAAAAATACGAATAAAAATATCGTTTACTGTACAACATATGAAACAATTCAGACGATCCTAGGGTTTGGTAT
GTTTACCATTGCTTTGATTGCGCTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9437.77 Da        Isoelectric Point: 4.4463

>AT181408 WP_001523745.1 NZ_CP064674:c4528377-4528135 [Salmonella sp. SJTUF14076]
MMAGMDMGRILLDLSDDVIKRLDDLKVQRNLPRAELLREAVEQYLERQDRAETTISKALGLWQGCEEDGVEYQRKLREEW

Download         Length: 243 bp

>AT181408 NZ_CP085841:c2790769-2790626 [Enterococcus faecalis]
TGCTACAATAGAGACGAAAAGAGAGGTATGCTCTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCTTTTTA
GTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I6CND8

Antitoxin

Source ID Structure

References