Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4107280..4107796 Replicon chromosome
Accession NZ_CP064674
Organism Salmonella sp. SJTUF14076

Toxin (Protein)


Gene name relE Uniprot ID A0A3V5VNJ7
Locus tag HU143_RS19805 Protein ID WP_000220577.1
Coordinates 4107280..4107564 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag HU143_RS19810 Protein ID WP_000212724.1
Coordinates 4107554..4107796 (-) Length 81 a.a.

Genomic Context

HU143_RS19790HU143_RS19795HU143_RS19800HU143_RS19805HU143_RS19810HU143_RS19815HU143_RS19820HU143_RS19825HU143_RS19830
Location: 4102396..4104048 (1653 bp)
Type: Others
Protein ID: WP_000155050.1
Location: 4104457..4106595 (2139 bp)
Type: Others
Protein ID: WP_023226981.1
Location: 4106812..4107276 (465 bp)
Type: Others
Protein ID: WP_001009173.1
Location: 4107280..4107564 (285 bp)
Type: Toxin
Protein ID: WP_000220577.1
Location: 4107554..4107796 (243 bp)
Type: Antitoxin
Protein ID: WP_000212724.1
Location: 4107874..4109787 (1914 bp)
Type: Others
Protein ID: WP_023226980.1
Location: 4109804..4110544 (741 bp)
Type: Others
Protein ID: WP_000779254.1
Location: 4110541..4111659 (1119 bp)
Type: Others
Protein ID: WP_023137277.1
Location: 4111643..4112776 (1134 bp)
Type: Others
Protein ID: WP_023226979.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HU143_RS197904102396..4104048+1653WP_000155050.1alpha,alpha-phosphotrehalase-
HU143_RS197954104457..4106595+2139WP_023226981.1anaerobic ribonucleoside-triphosphate reductase-
HU143_RS198004106812..4107276+465WP_001009173.1anaerobic ribonucleoside-triphosphate reductase-activating protein-
HU143_RS198054107280..4107564-285WP_000220577.1type II toxin-antitoxin system RelE/ParE family toxinToxin
HU143_RS198104107554..4107796-243WP_000212724.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
HU143_RS198154107874..4109787-1914WP_023226980.1BglG family transcription antiterminator-
HU143_RS198204109804..4110544-741WP_000779254.1KDGP aldolase family protein-
HU143_RS198254110541..4111659-1119WP_023137277.1DgaE family pyridoxal phosphate-dependent ammonia lyase-
HU143_RS198304111643..4112776-1134WP_023226979.1amidohydrolase/deacetylase family metallohydrolase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10912.71 Da        Isoelectric Point: 9.8739

>T181407 WP_000220577.1 NZ_CP064674:c4107564-4107280 [Salmonella sp. SJTUF14076]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T181407 NZ_CP085841:2790455-2790652 [Enterococcus faecalis]
ATGTGTAGAGAAGTTATGGCGGTGGCTATCCAATCTGAAAGAGAGGTGATGCGTATGCACGTATTTCCGAAATTTAGAGA
AAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGGTATGTTTACCATTGCTTTGATTGCGC
TGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT181407 WP_000212724.1 NZ_CP064674:c4107796-4107554 [Salmonella sp. SJTUF14076]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT181407 NZ_CP085841:c2790769-2790585 [Enterococcus faecalis]
TGCTACAATAGAGACGAAAAGAGAGGTATGCTCTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCTTTTTA
GTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCA
ATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A3V5VNJ7

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A5H5JRI5

References