Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2440901..2441423 Replicon chromosome
Accession NZ_CP064674
Organism Salmonella sp. SJTUF14076

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag HU143_RS11850 Protein ID WP_000221343.1
Coordinates 2441139..2441423 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag HU143_RS11845 Protein ID WP_000885424.1
Coordinates 2440901..2441149 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HU143_RS11825 2436543..2438009 + 1467 WP_023893409.1 hypothetical protein -
HU143_RS11830 2438626..2438874 + 249 Protein_2315 helix-turn-helix domain-containing protein -
HU143_RS11835 2438985..2439893 - 909 WP_077910000.1 hypothetical protein -
HU143_RS11840 2440044..2440376 - 333 WP_023227504.1 DUF1493 family protein -
HU143_RS11845 2440901..2441149 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HU143_RS11850 2441139..2441423 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HU143_RS11855 2441471..2441671 + 201 Protein_2320 RidA family protein -
HU143_RS11860 2441723..2442802 - 1080 WP_023227502.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
HU143_RS11865 2442995..2443483 - 489 WP_023227501.1 MarR family winged helix-turn-helix transcriptional regulator -
HU143_RS11870 2443528..2445036 + 1509 WP_023227500.1 FAD-dependent oxidoreductase -
HU143_RS11875 2445026..2446267 + 1242 WP_023227499.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2438058..2447893 9835


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T181402 WP_000221343.1 NZ_CP064674:2441139-2441423 [Salmonella sp. SJTUF14076]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T181402 NZ_CP085839:c3282130-3281705 [Nocardioides sp. Kera G14]
ATGAAACTCGTTGACGTCAACGTCCTCGTCTATGCCCGGGACTCTCAGTCTCCGCACCACCGTGCGGCCAAGCACTGGCT
CGACAGCGCCCTCTCTGGCAGTACCCCGGTCGGCTTCTCCTGGCTGGTGCTGATCGGCTTCGTCCGGCTGGTCACTCATC
CGCGGGTGATGGCCTCACCTCTGACGCCGGCCGAGGCAATGGCAACGGTCGATGCCTGGCTGGCGGCGCGATCTGCGCAG
GTCCTCCACCCGGGACAGAGCCACGCTCGCCTGATGGCGGAGATGCTGTCGGCGGTCGGTGTCGGAGGCAACCTCACCAA
CGACGCCCATCTCGCTGCGCTTGCGCTCGAGCATAGGGCCGCCATTGTCAGCTTCGACAGCGACTTCGAGCGGTTCCCCG
GTGTGAGGTGGGAGAAGCCGCGCTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT181402 WP_000885424.1 NZ_CP064674:2440901-2441149 [Salmonella sp. SJTUF14076]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT181402 NZ_CP085839:c3282372-3282127 [Nocardioides sp. Kera G14]
GTGCGTACGACGGTGACTCTGGATCCGGACGTCGAACAGCTGGTCCGGGAGCGGATGGCAGCGAAGGGCGTCTCGTTCAA
GCGCGCGCTCAACGATGCGATCCGCGAGAGCACGCCACGCGTTGACTACGTCTTCGAAACGCCCAGCTCGCCGCTCGGAC
TGAAGATTGATCTGGAGCACGCCGGCGCGGTGCTCAGCGACCTGGATGTCGACGACTTCCTGTCGAGTGCACACCGCGAT
CGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References