Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | stbDE/ParE-YafN |
Location | 2440901..2441423 | Replicon | chromosome |
Accession | NZ_CP064674 | ||
Organism | Salmonella sp. SJTUF14076 |
Toxin (Protein)
Gene name | stbE | Uniprot ID | B5F5Y5 |
Locus tag | HU143_RS11850 | Protein ID | WP_000221343.1 |
Coordinates | 2441139..2441423 (+) | Length | 95 a.a. |
Antitoxin (Protein)
Gene name | stbD | Uniprot ID | V1H457 |
Locus tag | HU143_RS11845 | Protein ID | WP_000885424.1 |
Coordinates | 2440901..2441149 (+) | Length | 83 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HU143_RS11825 | 2436543..2438009 | + | 1467 | WP_023893409.1 | hypothetical protein | - |
HU143_RS11830 | 2438626..2438874 | + | 249 | Protein_2315 | helix-turn-helix domain-containing protein | - |
HU143_RS11835 | 2438985..2439893 | - | 909 | WP_077910000.1 | hypothetical protein | - |
HU143_RS11840 | 2440044..2440376 | - | 333 | WP_023227504.1 | DUF1493 family protein | - |
HU143_RS11845 | 2440901..2441149 | + | 249 | WP_000885424.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
HU143_RS11850 | 2441139..2441423 | + | 285 | WP_000221343.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
HU143_RS11855 | 2441471..2441671 | + | 201 | Protein_2320 | RidA family protein | - |
HU143_RS11860 | 2441723..2442802 | - | 1080 | WP_023227502.1 | S-adenosylmethionine:tRNA ribosyltransferase-isomerase | - |
HU143_RS11865 | 2442995..2443483 | - | 489 | WP_023227501.1 | MarR family winged helix-turn-helix transcriptional regulator | - |
HU143_RS11870 | 2443528..2445036 | + | 1509 | WP_023227500.1 | FAD-dependent oxidoreductase | - |
HU143_RS11875 | 2445026..2446267 | + | 1242 | WP_023227499.1 | MFS transporter | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | - | 2438058..2447893 | 9835 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 95 a.a. Molecular weight: 11075.85 Da Isoelectric Point: 10.6500
>T181402 WP_000221343.1 NZ_CP064674:2441139-2441423 [Salmonella sp. SJTUF14076]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS
Download Length: 285 bp
>T181402 NZ_CP085839:c3282130-3281705 [Nocardioides sp. Kera G14]
ATGAAACTCGTTGACGTCAACGTCCTCGTCTATGCCCGGGACTCTCAGTCTCCGCACCACCGTGCGGCCAAGCACTGGCT
CGACAGCGCCCTCTCTGGCAGTACCCCGGTCGGCTTCTCCTGGCTGGTGCTGATCGGCTTCGTCCGGCTGGTCACTCATC
CGCGGGTGATGGCCTCACCTCTGACGCCGGCCGAGGCAATGGCAACGGTCGATGCCTGGCTGGCGGCGCGATCTGCGCAG
GTCCTCCACCCGGGACAGAGCCACGCTCGCCTGATGGCGGAGATGCTGTCGGCGGTCGGTGTCGGAGGCAACCTCACCAA
CGACGCCCATCTCGCTGCGCTTGCGCTCGAGCATAGGGCCGCCATTGTCAGCTTCGACAGCGACTTCGAGCGGTTCCCCG
GTGTGAGGTGGGAGAAGCCGCGCTGA
ATGAAACTCGTTGACGTCAACGTCCTCGTCTATGCCCGGGACTCTCAGTCTCCGCACCACCGTGCGGCCAAGCACTGGCT
CGACAGCGCCCTCTCTGGCAGTACCCCGGTCGGCTTCTCCTGGCTGGTGCTGATCGGCTTCGTCCGGCTGGTCACTCATC
CGCGGGTGATGGCCTCACCTCTGACGCCGGCCGAGGCAATGGCAACGGTCGATGCCTGGCTGGCGGCGCGATCTGCGCAG
GTCCTCCACCCGGGACAGAGCCACGCTCGCCTGATGGCGGAGATGCTGTCGGCGGTCGGTGTCGGAGGCAACCTCACCAA
CGACGCCCATCTCGCTGCGCTTGCGCTCGAGCATAGGGCCGCCATTGTCAGCTTCGACAGCGACTTCGAGCGGTTCCCCG
GTGTGAGGTGGGAGAAGCCGCGCTGA
Antitoxin
Download Length: 83 a.a. Molecular weight: 9090.32 Da Isoelectric Point: 3.9820
>AT181402 WP_000885424.1 NZ_CP064674:2440901-2441149 [Salmonella sp. SJTUF14076]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL
Download Length: 249 bp
>AT181402 NZ_CP085839:c3282372-3282127 [Nocardioides sp. Kera G14]
GTGCGTACGACGGTGACTCTGGATCCGGACGTCGAACAGCTGGTCCGGGAGCGGATGGCAGCGAAGGGCGTCTCGTTCAA
GCGCGCGCTCAACGATGCGATCCGCGAGAGCACGCCACGCGTTGACTACGTCTTCGAAACGCCCAGCTCGCCGCTCGGAC
TGAAGATTGATCTGGAGCACGCCGGCGCGGTGCTCAGCGACCTGGATGTCGACGACTTCCTGTCGAGTGCACACCGCGAT
CGATGA
GTGCGTACGACGGTGACTCTGGATCCGGACGTCGAACAGCTGGTCCGGGAGCGGATGGCAGCGAAGGGCGTCTCGTTCAA
GCGCGCGCTCAACGATGCGATCCGCGAGAGCACGCCACGCGTTGACTACGTCTTCGAAACGCCCAGCTCGCCGCTCGGAC
TGAAGATTGATCTGGAGCACGCCGGCGCGGTGCTCAGCGACCTGGATGTCGACGACTTCCTGTCGAGTGCACACCGCGAT
CGATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A5H5JSW4 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A5I0WPN5 |