Detailed information of TA system TA181392

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 879687..880312
• Replicon: chromosome
• Accession: NZ_CP064674
• Organism: Salmonella sp. SJTUF14076

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: HU143_RS04370
• Protein ID: WP_000911337.1
• Coordinates: 879914..880312 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: C0PXM4
• Locus tag: HU143_RS04365
• Protein ID: WP_000557545.1
• Coordinates: 879687..879914 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HU143_RS04335	874732..876249	+	1518	WP_000003339.1	lysine--tRNA ligase	-
HU143_RS04340	876325..876870	-	546	WP_000133994.1	isopentenyl-diphosphate Delta-isomerase	-
HU143_RS04345	877135..877893	+	759	WP_000244318.1	peptidoglycan DD-metalloendopeptidase family protein	-
HU143_RS04355	878178..878984	-	807	WP_010989071.1	DUF1460 domain-containing protein	-
HU143_RS04360	879259..879519	-	261	WP_023227725.1	hypothetical protein	-
HU143_RS04365	879687..879914	+	228	WP_000557545.1	toxin-antitoxin system antitoxin VapB	Antitoxin
HU143_RS04370	879914..880312	+	399	WP_000911337.1	tRNA(fMet)-specific endonuclease VapC	Toxin
HU143_RS04375	881116..881652	+	537	WP_023227726.1	STM3031 family outer membrane protein	-
HU143_RS04380	881699..882331	+	633	WP_023227727.1	YfdX family protein	-
HU143_RS04385	883050..883637	+	588	WP_023227728.1	fimbrial protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	878178..889505	11327

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-123)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 15037.43 Da
• Isoelectric Point: 7.7785

>T181392 WP_000911337.1 NZ_CP064674:879914-880312 [Salmonella sp. SJTUF14076]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Nucleotide

• Length: 399 bp

>T181392 NZ_CP085824:1188196-1188594 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCGGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAATTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8500.48 Da
• Isoelectric Point: 5.0053

>AT181392 WP_000557545.1 NZ_CP064674:879687-879914 [Salmonella sp. SJTUF14076]
MHTTLFFSNRTQAVRLPKSISFPDDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Nucleotide

• Length: 228 bp

>AT181392 NZ_CP085824:1187969-1188196 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGTAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTTTGA

Structures

Antitoxin

• AlphaFold DB: A0A0R9MGW6