Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 44767..45368 Replicon plasmid p14146
Accession NZ_CP064673
Organism Salmonella sp. SJTUF14146

Toxin (Protein)


Gene name doc Uniprot ID U9YA20
Locus tag IVP14_RS23250 Protein ID WP_001216045.1
Coordinates 44767..45147 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag IVP14_RS23255 Protein ID WP_001190712.1
Coordinates 45147..45368 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IVP14_RS23225 40207..41691 - 1485 WP_000124155.1 hypothetical protein -
IVP14_RS23230 41691..42884 - 1194 WP_000219604.1 terminase -
IVP14_RS23235 42971..43423 - 453 WP_001312282.1 late promoter-activating protein (Gp10) -
IVP14_RS23240 43512..44555 - 1044 WP_000648827.1 DUF968 domain-containing protein -
IVP14_RS23245 44583..44762 - 180 WP_001749393.1 hypothetical protein -
IVP14_RS23250 44767..45147 - 381 WP_001216045.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
IVP14_RS23255 45147..45368 - 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IVP14_RS23260 45441..45830 - 390 WP_000506730.1 DNA repair protein -
IVP14_RS23265 46005..46589 + 585 WP_001749394.1 hypothetical protein -
IVP14_RS23270 46590..46946 + 357 WP_001062545.1 hypothetical protein -
IVP14_RS23275 48022..48384 - 363 WP_001261543.1 hypothetical protein -
IVP14_RS23280 48381..49313 - 933 WP_001749396.1 hypothetical protein -
IVP14_RS23285 49295..49669 - 375 WP_001749397.1 hypothetical protein -
IVP14_RS23290 49676..49969 - 294 WP_000269004.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaCTX-M-27 - 1..103445 103445


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13588.29 Da        Isoelectric Point: 5.1514

>T181390 WP_001216045.1 NZ_CP064673:c45147-44767 [Salmonella sp. SJTUF14146]
MRHISPEELIALHDANISRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE

Download         Length: 381 bp

>T181390 NZ_CP085824:710965-711240 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8133.10 Da        Isoelectric Point: 4.7708

>AT181390 WP_001190712.1 NZ_CP064673:c45368-45147 [Salmonella sp. SJTUF14146]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp

>AT181390 NZ_CP085824:710702-710962 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCACGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CLP7

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References