Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4172108..4172624 Replicon chromosome
Accession NZ_CP064672
Organism Salmonella sp. SJTUF14146

Toxin (Protein)


Gene name relE Uniprot ID A0A3V5VNJ7
Locus tag IVP14_RS20170 Protein ID WP_000220577.1
Coordinates 4172108..4172392 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag IVP14_RS20175 Protein ID WP_000212724.1
Coordinates 4172382..4172624 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IVP14_RS20155 4167224..4168876 + 1653 WP_000155050.1 alpha,alpha-phosphotrehalase -
IVP14_RS20160 4169285..4171423 + 2139 WP_023226981.1 anaerobic ribonucleoside-triphosphate reductase -
IVP14_RS20165 4171640..4172104 + 465 WP_001009173.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
IVP14_RS20170 4172108..4172392 - 285 WP_000220577.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IVP14_RS20175 4172382..4172624 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
IVP14_RS20180 4172702..4174615 - 1914 WP_023226980.1 BglG family transcription antiterminator -
IVP14_RS20185 4174632..4175372 - 741 WP_000779254.1 KDGP aldolase family protein -
IVP14_RS20190 4175369..4176487 - 1119 WP_023137277.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
IVP14_RS20195 4176471..4177604 - 1134 WP_023226979.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10912.71 Da        Isoelectric Point: 9.8739

>T181387 WP_000220577.1 NZ_CP064672:c4172392-4172108 [Salmonella sp. SJTUF14146]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T181387 NZ_CP085824:162508-162819 [Salmonella enterica subsp. enterica serovar Enteritidis]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACACTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGCACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATGATCGGGGTAATAAAGAATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT181387 WP_000212724.1 NZ_CP064672:c4172624-4172382 [Salmonella sp. SJTUF14146]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT181387 NZ_CP085824:162816-163262 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAAGCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V5VNJ7

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References