Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3483658..3484278 Replicon chromosome
Accession NZ_CP064672
Organism Salmonella sp. SJTUF14146

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag IVP14_RS17040 Protein ID WP_001280991.1
Coordinates 3484060..3484278 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag IVP14_RS17035 Protein ID WP_000344807.1
Coordinates 3483658..3484032 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IVP14_RS17025 3478797..3479990 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
IVP14_RS17030 3480013..3483162 + 3150 WP_051129102.1 efflux RND transporter permease AcrB -
IVP14_RS17035 3483658..3484032 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
IVP14_RS17040 3484060..3484278 + 219 WP_001280991.1 hemolysin expression modulator Hha Toxin
IVP14_RS17045 3484457..3485008 + 552 WP_001278793.1 maltose O-acetyltransferase -
IVP14_RS17050 3485126..3485596 + 471 WP_000136181.1 membrane protein -
IVP14_RS17055 3485652..3485792 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
IVP14_RS17060 3485798..3486058 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
IVP14_RS17065 3486283..3487833 + 1551 WP_023210786.1 EAL domain-containing protein -
IVP14_RS17075 3488064..3488453 + 390 WP_000961285.1 MGMT family protein -
IVP14_RS17080 3488486..3489055 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T181383 WP_001280991.1 NZ_CP064672:3484060-3484278 [Salmonella sp. SJTUF14146]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T181383 NZ_CP085823:3446248-3446535 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGCTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCTCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT181383 WP_000344807.1 NZ_CP064672:3483658-3484032 [Salmonella sp. SJTUF14146]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT181383 NZ_CP085823:3446522-3446824 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAGCATGGTTAAACATAAACGCGGCAATGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References