181382

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2503366..2503888 Replicon chromosome
Accession NZ_CP064672
Organism Salmonella sp. SJTUF14146

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag IVP14_RS12200 Protein ID WP_000221343.1
Coordinates 2503604..2503888 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag IVP14_RS12195 Protein ID WP_000885424.1
Coordinates 2503366..2503614 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IVP14_RS12175 2499008..2500474 + 1467 WP_023893409.1 hypothetical protein -
IVP14_RS12180 2501091..2501339 + 249 Protein_2385 helix-turn-helix domain-containing protein -
IVP14_RS12185 2501450..2502358 - 909 WP_077910000.1 hypothetical protein -
IVP14_RS12190 2502509..2502841 - 333 WP_023227504.1 DUF1493 family protein -
IVP14_RS12195 2503366..2503614 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IVP14_RS12200 2503604..2503888 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IVP14_RS12205 2503936..2504136 + 201 Protein_2390 RidA family protein -
IVP14_RS12210 2504188..2505267 - 1080 WP_023227502.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
IVP14_RS12215 2505460..2505948 - 489 WP_023227501.1 MarR family winged helix-turn-helix transcriptional regulator -
IVP14_RS12220 2505993..2507501 + 1509 WP_023227500.1 FAD-dependent oxidoreductase -
IVP14_RS12225 2507491..2508732 + 1242 WP_023227499.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2500523..2510358 9835


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T181382 WP_000221343.1 NZ_CP064672:2503604-2503888 [Salmonella sp. SJTUF14146]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T181382 NZ_CP085823:3402255-3402563 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGATTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT181382 WP_000885424.1 NZ_CP064672:2503366-2503614 [Salmonella sp. SJTUF14146]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT181382 NZ_CP085823:3402013-3402252 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCAGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References