Detailed information of TA system TA181373

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 1082828..1083642
• Replicon: chromosome
• Accession: NZ_CP064672
• Organism: Salmonella sp. SJTUF14146

Toxin (Protein)

• Gene name: TacT3
• Uniprot ID: A0A4Y6MAM1
• Locus tag: IVP14_RS05335
• Protein ID: WP_023227563.1
• Coordinates: 1082828..1083355 (-)
• Length: 176 a.a.

Antitoxin (Protein)

• Gene name: TacA3
• Uniprot ID: A0A4Y6M833
• Locus tag: IVP14_RS05340
• Protein ID: WP_072162154.1
• Coordinates: 1083352..1083642 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IVP14_RS05305	1079129..1079527	+	399	Protein_1041	cytoplasmic protein	-
IVP14_RS05310	1079738..1079905	+	168	Protein_1042	transposase	-
IVP14_RS05315	1080113..1080781	+	669	WP_000445914.1	hypothetical protein	-
IVP14_RS05320	1080808..1081302	+	495	WP_023227564.1	hypothetical protein	-
IVP14_RS05325	1081547..1082203	-	657	WP_000420452.1	protein-serine/threonine phosphatase	-
IVP14_RS05330	1082532..1082755	+	224	Protein_1046	IS5/IS1182 family transposase	-
IVP14_RS05335	1082828..1083355	-	528	WP_023227563.1	GNAT family N-acetyltransferase	Toxin
IVP14_RS05340	1083352..1083642	-	291	WP_072162154.1	DUF1778 domain-containing protein	Antitoxin
IVP14_RS05345	1083912..1084090	-	179	Protein_1049	IS3 family transposase	-
IVP14_RS05350	1084331..1084657	+	327	WP_000393302.1	hypothetical protein	-
IVP14_RS05355	1084930..1085277	-	348	WP_001669174.1	DUF1493 family protein	-
IVP14_RS05360	1085262..1085711	-	450	WP_000381610.1	membrane protein	-
IVP14_RS05365	1086142..1086585	-	444	WP_000715096.1	SPI-1 type III secretion system invasion lipoprotein InvH	-
IVP14_RS05370	1087041..1087691	+	651	WP_001674874.1	type III secretion system transcriptional activator InvF	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	invH / invF / invG / invE / invA / invB	1082615..1093004	10389
	-	flank	IS/Tn	-	-	1082615..1082755	140

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (1-95)

Sequences

Toxin

Protein

• Length: 176 a.a.
• Molecular weight: 19099.93 Da
• Isoelectric Point: 9.6420

>T181373 WP_023227563.1 NZ_CP064672:c1083355-1082828 [Salmonella sp. SJTUF14146]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGSVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Nucleotide

• Length: 528 bp

>T181373 NZ_CP085823:c1917898-1917500 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCGGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAATTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10664.54 Da
• Isoelectric Point: 8.5779

>AT181373 WP_072162154.1 NZ_CP064672:c1083642-1083352 [Salmonella sp. SJTUF14146]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Nucleotide

• Length: 291 bp

>AT181373 NZ_CP085823:c1918125-1917898 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGTAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTTTGA

Structures

Toxin

• AlphaFold DB: A0A4Y6MAM1

Antitoxin

• AlphaFold DB: A0A4Y6M833