Detailed information of TA system TA181372

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 926520..927145
• Replicon: chromosome
• Accession: NZ_CP064672
• Organism: Salmonella sp. SJTUF14146

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: IVP14_RS04635
• Protein ID: WP_000911337.1
• Coordinates: 926747..927145 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: C0PXM4
• Locus tag: IVP14_RS04630
• Protein ID: WP_000557545.1
• Coordinates: 926520..926747 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IVP14_RS04600	921565..923082	+	1518	WP_000003339.1	lysine--tRNA ligase	-
IVP14_RS04605	923158..923703	-	546	WP_000133994.1	isopentenyl-diphosphate Delta-isomerase	-
IVP14_RS04610	923968..924726	+	759	WP_000244318.1	peptidoglycan DD-metalloendopeptidase family protein	-
IVP14_RS04620	925011..925817	-	807	WP_010989071.1	DUF1460 domain-containing protein	-
IVP14_RS04625	926092..926352	-	261	WP_023227725.1	hypothetical protein	-
IVP14_RS04630	926520..926747	+	228	WP_000557545.1	toxin-antitoxin system antitoxin VapB	Antitoxin
IVP14_RS04635	926747..927145	+	399	WP_000911337.1	tRNA(fMet)-specific endonuclease VapC	Toxin
IVP14_RS04640	927949..928485	+	537	WP_023227726.1	STM3031 family outer membrane protein	-
IVP14_RS04645	928532..929164	+	633	WP_023227727.1	YfdX family protein	-
IVP14_RS04650	929883..930470	+	588	WP_023227728.1	fimbrial protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	925011..936338	11327

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-123)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 15037.43 Da
• Isoelectric Point: 7.7785

>T181372 WP_000911337.1 NZ_CP064672:926747-927145 [Salmonella sp. SJTUF14146]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Nucleotide

• Length: 399 bp

>T181372 NZ_CP085823:1765035-1765562 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8500.48 Da
• Isoelectric Point: 5.0053

>AT181372 WP_000557545.1 NZ_CP064672:926520-926747 [Salmonella sp. SJTUF14146]
MHTTLFFSNRTQAVRLPKSISFPDDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Nucleotide

• Length: 228 bp

>AT181372 NZ_CP085823:1764748-1765038 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTGCGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0R9MGW6