Detailed information of TA system TA181370

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 163548..165171
• Replicon: chromosome
• Accession: NZ_CP064672
• Organism: Salmonella sp. SJTUF14146

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: H9TH67
• Locus tag: IVP14_RS00815
• Protein ID: WP_000088046.1
• Coordinates: 163846..165171 (+)
• Length: 442 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A5Z6V2D1
• Locus tag: IVP14_RS00810
• Protein ID: WP_024136327.1
• Coordinates: 163548..163841 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IVP14_RS00780	159047..159391	-	345	WP_001805195.1	hypothetical protein	-
IVP14_RS00785	159327..160232	-	906	WP_001198594.1	hypothetical protein	-
IVP14_RS00790	160242..160802	-	561	Protein_156	DNA replication protein	-
IVP14_RS00795	160867..161571	+	705	WP_001067858.1	IS6-like element IS26 family transposase	-
IVP14_RS00800	161838..162179	-	342	WP_001151575.1	hypothetical protein	-
IVP14_RS00805	162552..162944	+	393	WP_000341066.1	hypothetical protein	-
IVP14_RS00810	163548..163841	+	294	WP_024136327.1	helix-turn-helix transcriptional regulator	Antitoxin
IVP14_RS00815	163846..165171	+	1326	WP_000088046.1	type II toxin-antitoxin system HipA family toxin	Toxin
IVP14_RS00820	165232..165438	+	207	WP_000134171.1	hypothetical protein	-
IVP14_RS00825	165540..165950	+	411	WP_000985911.1	hypothetical protein	-
IVP14_RS00830	165963..166778	+	816	WP_053276223.1	HNH endonuclease	-
IVP14_RS00835	167032..167457	+	426	WP_001043843.1	hypothetical protein	-
IVP14_RS00840	168006..168314	+	309	WP_001224687.1	hypothetical protein	-
IVP14_RS00845	168330..169187	+	858	WP_000784387.1	HNH endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	tet(A) / sul1 / qacE / ARR-3 / catB3 / blaOXA-1 / aac(6')-Ib-cr / aac(3)-IVa / aph(4)-Ia / sul2 / floR / sul3 / ant(3'')-Ia / cmlA1 / aadA2 / aph(3')-Ia / dfrA12	-	159047..231723	72676

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (9-108)

Antitoxin

• Cro/C1-type helix-turn-helix domain (21-69)

Sequences

Toxin

Protein

• Length: 442 a.a.
• Molecular weight: 50249.20 Da
• Isoelectric Point: 6.1927

>T181370 WP_000088046.1 NZ_CP064672:163846-165171 [Salmonella sp. SJTUF14146]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Nucleotide

• Length: 1326 bp

>T181370 NZ_CP085823:60483-60586 [Salmonella enterica subsp. enterica serovar Enteritidis]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10946.35 Da
• Isoelectric Point: 10.0925

>AT181370 WP_024136327.1 NZ_CP064672:163548-163841 [Salmonella sp. SJTUF14146]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Nucleotide

• Length: 294 bp

>AT181370 NZ_CP085823:c60588-60443 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Structures

Toxin

• AlphaFold DB: A0A3T0VBU1

Antitoxin

• AlphaFold DB: A0A5Z6V2D1