Detailed information of TA system TA181368

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1(toxin)
• Location: 4801665..4802281
• Replicon: chromosome
• Accession: NZ_CP064671
• Organism: Salmonella sp. SJTUF14152

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q8Z2U3
• Locus tag: IVP15_RS23365
• Protein ID: WP_000238494.1
• Coordinates: 4801665..4802039 (-)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A8E9YHE9
• Locus tag: IVP15_RS23370
• Protein ID: WP_001523745.1
• Coordinates: 4802039..4802281 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IVP15_RS23350	4799167..4800069	+	903	WP_051129234.1	formate dehydrogenase subunit beta	-
IVP15_RS23355	4800066..4800701	+	636	WP_000829028.1	formate dehydrogenase cytochrome b556 subunit	-
IVP15_RS23360	4800698..4801627	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
IVP15_RS23365	4801665..4802039	-	375	WP_000238494.1	type II toxin-antitoxin system VapC family toxin	Toxin
IVP15_RS23370	4802039..4802281	-	243	WP_001523745.1	ribbon-helix-helix domain-containing protein	Antitoxin
IVP15_RS23375	4802486..4803415	+	930	WP_001162861.1	alpha/beta hydrolase	-
IVP15_RS23380	4803501..4803812	+	312	WP_000558165.1	type II toxin-antitoxin system HigB family toxin	-
IVP15_RS23385	4803809..4804255	+	447	WP_001259009.1	type II toxin-antitoxin system HigA family antitoxin	-
IVP15_RS23390	4804270..4805211	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
IVP15_RS23395	4805256..4805693	-	438	WP_000560969.1	D-tyrosyl-tRNA(Tyr) deacylase	-
IVP15_RS23400	4805690..4806562	-	873	WP_000921423.1	virulence factor BrkB family protein	-
IVP15_RS23405	4806556..4807155	-	600	WP_023227076.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (7-115)

Antitoxin

• Ribbon-helix-helix protein, CopG (13-47)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 13908.18 Da
• Isoelectric Point: 7.3567

>T181368 WP_000238494.1 NZ_CP064671:c4802039-4801665 [Salmonella sp. SJTUF14152]
MVKGSALFDTNILIDLFSGRIEAKHALEAYPPQNAISLITWMEVMVGAKKYHQENRTRIALSAFNIIGVTQEIAERSVIV
RQEYGMKLPDAIILATAQVHRCELVTRNTKDFADIPGVITPYHL

Nucleotide

• Length: 375 bp

>T181368 NZ_CP085822:4350489-4350887 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCGGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAATTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9437.77 Da
• Isoelectric Point: 4.4463

>AT181368 WP_001523745.1 NZ_CP064671:c4802281-4802039 [Salmonella sp. SJTUF14152]
MMAGMDMGRILLDLSDDVIKRLDDLKVQRNLPRAELLREAVEQYLERQDRAETTISKALGLWQGCEEDGVEYQRKLREEW

Nucleotide

• Length: 243 bp

>AT181368 NZ_CP085822:4350262-4350489 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGTAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTTTGA

Structures

Toxin

• AlphaFold DB: A0A5I6CND8