Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3528147..3528767 Replicon chromosome
Accession NZ_CP064671
Organism Salmonella sp. SJTUF14152

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag IVP15_RS17240 Protein ID WP_001280991.1
Coordinates 3528549..3528767 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag IVP15_RS17235 Protein ID WP_000344807.1
Coordinates 3528147..3528521 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IVP15_RS17225 3523286..3524479 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
IVP15_RS17230 3524502..3527651 + 3150 WP_051129102.1 efflux RND transporter permease AcrB -
IVP15_RS17235 3528147..3528521 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
IVP15_RS17240 3528549..3528767 + 219 WP_001280991.1 hemolysin expression modulator Hha Toxin
IVP15_RS17245 3528946..3529497 + 552 WP_001278793.1 maltose O-acetyltransferase -
IVP15_RS17250 3529615..3530085 + 471 WP_000136181.1 membrane protein -
IVP15_RS17255 3530141..3530281 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
IVP15_RS17260 3530287..3530547 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
IVP15_RS17265 3530772..3532322 + 1551 WP_023210786.1 EAL domain-containing protein -
IVP15_RS17275 3532553..3532942 + 390 WP_000961285.1 MGMT family protein -
IVP15_RS17280 3532975..3533544 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T181363 WP_001280991.1 NZ_CP064671:3528549-3528767 [Salmonella sp. SJTUF14152]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T181363 NZ_CP085822:3324801-3325112 [Salmonella enterica subsp. enterica serovar Enteritidis]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACACTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGCACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATGATCGGGGTAATAAAGAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT181363 WP_000344807.1 NZ_CP064671:3528147-3528521 [Salmonella sp. SJTUF14152]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT181363 NZ_CP085822:3325109-3325555 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAAGCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References