Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2550115..2550637 Replicon chromosome
Accession NZ_CP064671
Organism Salmonella sp. SJTUF14152

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag IVP15_RS12420 Protein ID WP_000221343.1
Coordinates 2550353..2550637 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag IVP15_RS12415 Protein ID WP_000885424.1
Coordinates 2550115..2550363 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IVP15_RS12395 2545757..2547223 + 1467 WP_023893409.1 hypothetical protein -
IVP15_RS12400 2547840..2548088 + 249 Protein_2429 helix-turn-helix domain-containing protein -
IVP15_RS12405 2548199..2549107 - 909 WP_077910000.1 hypothetical protein -
IVP15_RS12410 2549258..2549590 - 333 WP_023227504.1 DUF1493 family protein -
IVP15_RS12415 2550115..2550363 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IVP15_RS12420 2550353..2550637 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IVP15_RS12425 2550685..2550885 + 201 Protein_2434 RidA family protein -
IVP15_RS12430 2550937..2552016 - 1080 WP_023227502.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
IVP15_RS12435 2552209..2552697 - 489 WP_023227501.1 MarR family winged helix-turn-helix transcriptional regulator -
IVP15_RS12440 2552742..2554250 + 1509 WP_023227500.1 FAD-dependent oxidoreductase -
IVP15_RS12445 2554240..2555481 + 1242 WP_023227499.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2547272..2557107 9835


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T181362 WP_000221343.1 NZ_CP064671:2550353-2550637 [Salmonella sp. SJTUF14152]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T181362 NZ_CP085822:c3323568-3323257 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGAGGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT181362 WP_000885424.1 NZ_CP064671:2550115-2550363 [Salmonella sp. SJTUF14152]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT181362 NZ_CP085822:c3323256-3322966 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References