Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1562231..1563854 Replicon chromosome
Accession NZ_CP064671
Organism Salmonella sp. SJTUF14152

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag IVP15_RS07495 Protein ID WP_000088046.1
Coordinates 1562231..1563556 (-) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag IVP15_RS07500 Protein ID WP_024136327.1
Coordinates 1563561..1563854 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IVP15_RS07465 1558215..1559072 - 858 WP_000784387.1 HNH endonuclease -
IVP15_RS07470 1559088..1559396 - 309 WP_001224687.1 hypothetical protein -
IVP15_RS07475 1559945..1560370 - 426 WP_001043843.1 hypothetical protein -
IVP15_RS07480 1560624..1561439 - 816 WP_053276223.1 HNH endonuclease -
IVP15_RS07485 1561452..1561862 - 411 WP_000985911.1 hypothetical protein -
IVP15_RS07490 1561964..1562170 - 207 WP_000134171.1 hypothetical protein -
IVP15_RS07495 1562231..1563556 - 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
IVP15_RS07500 1563561..1563854 - 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
IVP15_RS07505 1564458..1564850 - 393 WP_000341066.1 hypothetical protein -
IVP15_RS07510 1565223..1565564 + 342 WP_001151575.1 hypothetical protein -
IVP15_RS07515 1565656..1565847 + 192 WP_000398480.1 hypothetical protein -
IVP15_RS07520 1565897..1566178 + 282 WP_000077926.1 hypothetical protein -
IVP15_RS07525 1566741..1567982 - 1242 WP_001053338.1 VWA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island aadA2 / cmlA1 / ant(3'')-Ia / sul3 / aph(3')-Ia / mph(A) / floR / sul2 / aph(4)-Ia / aac(3)-IVa - 1549745..1607523 57778


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T181353 WP_000088046.1 NZ_CP064671:c1563556-1562231 [Salmonella sp. SJTUF14152]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

>T181353 NZ_CP085821:4557566-4557877 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGAGGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT181353 WP_024136327.1 NZ_CP064671:c1563854-1563561 [Salmonella sp. SJTUF14152]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp

>AT181353 NZ_CP085821:4557878-4558168 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References