Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1054140..1054954 Replicon chromosome
Accession NZ_CP064671
Organism Salmonella sp. SJTUF14152

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A4Y6MAM1
Locus tag IVP15_RS05120 Protein ID WP_023227563.1
Coordinates 1054140..1054667 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID A0A4Y6M833
Locus tag IVP15_RS05125 Protein ID WP_072162154.1
Coordinates 1054664..1054954 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IVP15_RS05090 1050441..1050839 + 399 Protein_998 cytoplasmic protein -
IVP15_RS05095 1051050..1051217 + 168 Protein_999 transposase -
IVP15_RS05100 1051425..1052093 + 669 WP_000445914.1 hypothetical protein -
IVP15_RS05105 1052120..1052614 + 495 WP_023227564.1 hypothetical protein -
IVP15_RS05110 1052859..1053515 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
IVP15_RS05115 1053844..1054067 + 224 Protein_1003 IS5/IS1182 family transposase -
IVP15_RS05120 1054140..1054667 - 528 WP_023227563.1 GNAT family N-acetyltransferase Toxin
IVP15_RS05125 1054664..1054954 - 291 WP_072162154.1 DUF1778 domain-containing protein Antitoxin
IVP15_RS05130 1055224..1055402 - 179 Protein_1006 IS3 family transposase -
IVP15_RS05135 1055643..1055969 + 327 WP_000393302.1 hypothetical protein -
IVP15_RS05140 1056242..1056589 - 348 WP_001669174.1 DUF1493 family protein -
IVP15_RS05145 1056574..1057023 - 450 WP_000381610.1 membrane protein -
IVP15_RS05150 1057454..1057897 - 444 WP_000715096.1 SPI-1 type III secretion system invasion lipoprotein InvH -
IVP15_RS05155 1058199..1058896 + 698 Protein_1011 IS1 family transposase -
IVP15_RS05160 1059130..1059780 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - invH / invF / invG / invE / invA / invB 1052859..1065093 12234
- inside IScluster/Tn - invH 1053927..1058896 4969


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19099.93 Da        Isoelectric Point: 9.6420

>T181352 WP_023227563.1 NZ_CP064671:c1054667-1054140 [Salmonella sp. SJTUF14152]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGSVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T181352 NZ_CP085821:c4556333-4556022 [Salmonella enterica subsp. enterica serovar Enteritidis]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACACTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGCACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATGATCGGGGTAATAAAGAATGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.54 Da        Isoelectric Point: 8.5779

>AT181352 WP_072162154.1 NZ_CP064671:c1054954-1054664 [Salmonella sp. SJTUF14152]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT181352 NZ_CP085821:c4556025-4555579 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAAGCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Y6MAM1

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y6M833

References