Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 184338..185961 Replicon plasmid p14154A
Accession NZ_CP064667
Organism Salmonella sp. SJTUF14154

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag IVP16_RS23720 Protein ID WP_000088046.1
Coordinates 184636..185961 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag IVP16_RS23715 Protein ID WP_024136327.1
Coordinates 184338..184631 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IVP16_RS23690 180210..181451 + 1242 WP_001053338.1 VWA domain-containing protein -
IVP16_RS23695 182014..182295 - 282 WP_000077926.1 hypothetical protein -
IVP16_RS23700 182345..182536 - 192 WP_000398480.1 hypothetical protein -
IVP16_RS23705 182628..182969 - 342 WP_001151575.1 hypothetical protein -
IVP16_RS23710 183342..183734 + 393 WP_000341066.1 hypothetical protein -
IVP16_RS23715 184338..184631 + 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
IVP16_RS23720 184636..185961 + 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
IVP16_RS23725 186022..186228 + 207 WP_000134171.1 hypothetical protein -
IVP16_RS23730 186330..186740 + 411 WP_000985911.1 hypothetical protein -
IVP16_RS23735 186753..187568 + 816 WP_001572439.1 HNH endonuclease -
IVP16_RS23740 187822..188247 + 426 WP_001043843.1 hypothetical protein -
IVP16_RS23745 188705..188940 + 236 Protein_198 type I restriction-modification system subunit M N-terminal domain-containing protein -
IVP16_RS23750 188995..189294 + 300 WP_001572440.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid fosA3 / blaTEM-1B / mph(A) / qepA1 / rmtB / aadA2 / cmlA1 / ant(3'')-Ia / blaCTX-M-65 / aac(6')-Ib-cr / blaOXA-1 / catB3 / ARR-3 / qacE / sul1 / aac(3)-IVa / aph(4)-Ia / sul2 / floR / aph(3'')-Ib / aph(6)-Id / aadA5 / dfrA17 - 1..202724 202724


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T181348 WP_000088046.1 NZ_CP064667:184636-185961 [Salmonella sp. SJTUF14154]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

>T181348 NZ_CP085821:c3541549-3541136 [Salmonella enterica subsp. enterica serovar Enteritidis]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT181348 WP_024136327.1 NZ_CP064667:184338-184631 [Salmonella sp. SJTUF14154]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp

>AT181348 NZ_CP085821:c3541796-3541530 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGACGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References