Detailed information of TA system TA181346

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1(toxin)
• Location: 4550797..4551413
• Replicon: chromosome
• Accession: NZ_CP064666
• Organism: Salmonella sp. SJTUF14154

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q8Z2U3
• Locus tag: IVP16_RS21800
• Protein ID: WP_000238494.1
• Coordinates: 4550797..4551171 (-)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A8E9YHE9
• Locus tag: IVP16_RS21805
• Protein ID: WP_001523745.1
• Coordinates: 4551171..4551413 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IVP16_RS21785	4548299..4549201	+	903	WP_051129234.1	formate dehydrogenase subunit beta	-
IVP16_RS21790	4549198..4549833	+	636	WP_000829028.1	formate dehydrogenase cytochrome b556 subunit	-
IVP16_RS21795	4549830..4550759	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
IVP16_RS21800	4550797..4551171	-	375	WP_000238494.1	type II toxin-antitoxin system VapC family toxin	Toxin
IVP16_RS21805	4551171..4551413	-	243	WP_001523745.1	ribbon-helix-helix domain-containing protein	Antitoxin
IVP16_RS21810	4551618..4552547	+	930	WP_001162861.1	alpha/beta hydrolase	-
IVP16_RS21815	4552633..4552944	+	312	WP_000558165.1	type II toxin-antitoxin system HigB family toxin	-
IVP16_RS21820	4552941..4553387	+	447	WP_001259009.1	type II toxin-antitoxin system HigA family antitoxin	-
IVP16_RS21825	4553402..4554343	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
IVP16_RS21830	4554388..4554825	-	438	WP_000560969.1	D-tyrosyl-tRNA(Tyr) deacylase	-
IVP16_RS21835	4554822..4555694	-	873	WP_000921423.1	virulence factor BrkB family protein	-
IVP16_RS21840	4555688..4556287	-	600	WP_023227076.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (7-115)

Antitoxin

• Ribbon-helix-helix protein, CopG (13-47)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 13908.18 Da
• Isoelectric Point: 7.3567

>T181346 WP_000238494.1 NZ_CP064666:c4551171-4550797 [Salmonella sp. SJTUF14154]
MVKGSALFDTNILIDLFSGRIEAKHALEAYPPQNAISLITWMEVMVGAKKYHQENRTRIALSAFNIIGVTQEIAERSVIV
RQEYGMKLPDAIILATAQVHRCELVTRNTKDFADIPGVITPYHL

Nucleotide

• Length: 375 bp

>T181346 NZ_CP085821:3377782-3378309 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9437.77 Da
• Isoelectric Point: 4.4463

>AT181346 WP_001523745.1 NZ_CP064666:c4551413-4551171 [Salmonella sp. SJTUF14154]
MMAGMDMGRILLDLSDDVIKRLDDLKVQRNLPRAELLREAVEQYLERQDRAETTISKALGLWQGCEEDGVEYQRKLREEW

Nucleotide

• Length: 243 bp

>AT181346 NZ_CP085821:3377495-3377785 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTGCGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Structures

Toxin

• AlphaFold DB: A0A5I6CND8